ʻO Sacubitril Hemicalcium
| 沙库比曲半钙盐 | ʻO Sacubitril Hemicalcium | 1369773-39-6 | I-Hale |
| 沙库比曲钠盐 | 149690-05-1 | I-Hale | |
| LCZ-4 | 1426129-50-1 | I-Hale | |
| LCZ-7 | 1012341-48-8 | I-Hale | |
| LCZ-8 | 1012341-50-2 | I-Hale | |
| LCZ-9 | 149690-12-0 | I-Hale |
Kāpae
ʻO ka paʻakai hemicalcium AHU-377 he ʻano paʻakai hemicalcium o AHU-377. He mea pale ia o neprilysin me ka waiwai IC50 o 5 nM [1].
AHU-377 a me ka angiotensin II AT1 receptor antagonist valsartan haku LCZ696 i ka 1:1 molar ratio. ʻO LCZ696 kahi mea hoʻopale neprilysin receptor angiotensin. Hiki iā ia ke hōʻemi i ke kahe koko a he lāʻau hou paha ia no ka mālama ʻana i ka hemahema o ka naʻau. ʻO AHU-377 kahi lāʻau lapaʻau, hiki ke hoʻololi ʻia e ka enzymatic cleavage o ka ethyl ester i loko o ke ʻano hana LBQ657. Ua hōʻike ʻia ʻo AHU-377(30 a me 100 mg/kg, PO) hiki ke hana i ka hopena antihypertensive ma ke ʻano i hilinaʻi ʻia i nā ʻiole DAHI-SS. Akā i ka DOCA-salt hypertensive rats, hōʻike ia i kahi emi nāwaliwali [2, 3].
Kuhikuhi:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 Mei 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. ʻO ke kuleana kūpono o valsartan + AHU377 (LCZ696) i ka mālama ʻana i ka naʻau. Opin Investig Drugs. 2013 ʻAukake;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Hoʻohālikelike ka maikaʻi o AHU-377, he mea hoʻopaneʻe neprilysin ikaika, i loko o ʻelua mau ʻiole o ke kiʻekiʻe kiʻekiʻe. BMC Pharmacology 2011, 11(Suppl 1):P33.
ʻO ke kinona
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