ʻO Sacubitril Hemicalcium

ʻO ka wehewehe pōkole:

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ʻO Sacubitril Hemicalcium   I-Hale      


Huahana Huahana

Huahana Huahana

NUI HUA

沙库比曲半钙盐 ʻO Sacubitril Hemicalcium 1369773-39-6 I-Hale
沙库比曲钠盐 149690-05-1 I-Hale
LCZ-4 1426129-50-1 I-Hale
LCZ-7 1012341-48-8 I-Hale
LCZ-8 1012341-50-2 I-Hale
LCZ-9 149690-12-0 I-Hale

 

Ka hope

ʻO ka paʻakai hemicalcium AHU-377 he ʻano paʻakai hemicalcium o AHU-377.He mea hoʻopale ia o neprilysin me ka waiwai IC50 o 5 nM [1].

AHU-377 a me ka angiotensin II AT1 receptor antagonist valsartan haku LCZ696 i ka 1:1 molar ratio.ʻO LCZ696 kahi mea hoʻopaneʻe neprilysin receptor angiotensin.Hiki iā ia ke hōʻemi i ke kahe koko a he lāʻau hou paha ia no ka mālama ʻana i ka hemahema o ka naʻau.ʻO ka AHU-377 kahi lāʻau lapaʻau, hiki ke hoʻololi ʻia e ka enzymatic cleavage o ka ethyl ester i loko o ke ʻano hana LBQ657.Ua hōʻike ʻia ʻo AHU-377(30 a me 100 mg/kg, PO) hiki ke hana i ka hopena antihypertensive ma ke ʻano i hilinaʻi ʻia i nā ʻiole DAHI-SS.Akā i ka DOCA-salt hypertensive rats, hōʻike ia i kahi hōʻemi nāwaliwali [2, 3].

Kuhikuhi:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.J Med Chem.1995 Mei 12;38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. ʻO ke kuleana kūpono o valsartan + AHU377 (LCZ696) i ka mālama ʻana i ka naʻau.Opin Investig Drugs.2013 ʻAukake;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al.Hoʻohālikelike ka maikaʻi o ka AHU-377, he mea hoʻopaneʻe neprilysin ikaika, ma nā ʻano ʻiole ʻelua o ke kiʻekiʻe e pili ana i ka nui.BMC Pharmacology 2011, 11(Suppl 1):P33.

ʻO ke kinona

Sacubitril Hemicalcium

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