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ʻO Bictegravir kahi puke moʻolelo, hoʻopaneʻe ikaika o HIV-1 integrase me kahi IC50 o 7.5 nM.

In Vitro

Kāohi ʻo Bictegravir (BIC) i ka hana hoʻoili strand me kahi IC50 o 7.5± 0.3 nM.E pili ana i kona kaohi ʻana i ka hana hoʻoili strand, ʻo Bictegravir kahi mea ʻoi aku ka nāwaliwali o 3.'- ka hana hoʻoponopono o HIV-1 IN, me kahi IC50 o 241±51 nM.Hoʻonui ʻo Bictegravir i ka hōʻiliʻili ʻana o nā pōʻai 2-LTR ~5-fold e pili ana i ka mana hoʻomāʻewaʻewa ʻia a hoʻemi i ka nui o nā huahana hoʻohui maoli i loko o nā cell i maʻi ʻia e 100-fold.Hoʻopaʻa ikaika ʻo Bictegravir i ka hoʻopiʻi hou ʻana o HIV-1 ma MT-2 a me MT-4 me nā EC50s o 1.5 a me 2.4 nM, kēlā me kēia.Hōʻike ʻo Bictegravir i nā hopena antiviral ikaika i nā lymphocytes CD4+ T mua a me nā macrophages i loaʻa i ka monocyte, me nā EC50 o 1.5±0.3 nM a me 6.6±4.1 nM, kēlā me kēia, i hoʻohālikelike ʻia me nā waiwai i loaʻa ma nā laina T-cell [1].

ʻAʻole ʻo MCE i hōʻoia kūʻokoʻa i ka pololei o kēia mau ʻano.No ka kuhikuhi wale no.

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