wehewehe

ʻO Pitavastatin Calcium (NK-104 hemicalcium) kahi mea hoʻopaneʻe reductase ikaika hydroxymethylglutaryl-CoA (HMG-CoA).ʻO Pitavastatin Calcium (NK-104 hemicalcium) ke kāohi nei i ka cholesterol synthesis mai ka acetic acid me kahi IC50 o 5.8 nM i loko o nā pūnaewele HepG2.ʻO Pitavastatin Calcium kahi mea hoʻokomo inducer lipoprotein-cholesterol (LDL-C) haʻahaʻa haʻahaʻa haʻahaʻa hepatocyte.Hana kūʻē i ke kanesa.

Ka hope

ʻO Pitavastatin Calcium kahi mea hoʻokūkū hoʻokūkū o ka enzyme HMGCR (HMG-CoA reductase) i hopena i ka hōʻemi ʻana i ka synthesis LDL cholesterol.Hōʻike nā haʻawina ʻē aʻe e hiki i ka pitavastatin ke hoʻopau i ka hana ʻana o ka oxygen i nā cell endothelial ma ke kāohi ʻana i ka NADPH oxidase.Eia kekahi, hōʻemi ka pitavastatin i ka hōʻike ʻana o ka eNOS mRNA aʻo ka hoʻonui ʻana i ka pane hilinaʻi NO i hoʻoulu ʻia e ka acetylcholine a me ka calcium ionophore, A23187.Eia kekahi, ke kāohi nei ʻo pitavastatin i ka hoʻoponopono ʻana o ka conductance calcium-activated potassium channel ma ka hoʻohaʻahaʻa ʻana i nā pae cholesterol i nā cell.

Waihona

4°C, pale mai ka malamalama

*Ma ka solvent: -80°C, 6 mahina;-20°C, 1 mahina (pale mai ka malamalama)

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