wehewehe

ʻO Pitavastatin Calcium (NK-104 hemicalcium) kahi mea hoʻopaneʻe reductase ikaika hydroxymethylglutaryl-CoA (HMG-CoA). ʻO Pitavastatin Calcium (NK-104 hemicalcium) ke kāohi nei i ka cholesterol synthesis mai ka acetic acid me kahi IC50 o 5.8 nM i nā pūnaewele HepG2. ʻO Pitavastatin Calcium kahi mea hoʻokomo inducer lipoprotein-cholesterol (LDL-C) haʻahaʻa haʻahaʻa haʻahaʻa hepatocyte. Hana kūʻē i ke kanesa.

Kāpae

ʻO Pitavastatin Calcium kahi mea hoʻokūkū hoʻokūkū o ka enzyme HMGCR (HMG-CoA reductase) i hopena i ka hōʻemi ʻana i ka synthesis LDL cholesterol. Hōʻike nā haʻawina ʻē aʻe e hiki i ka pitavastatin ke kāohi i ka hana o ka oxygen i loko o nā cell endothelial ma ke kāohi ʻana i ka NADPH oxidase. Eia kekahi, hōʻemi ka pitavastatin i ka hōʻike o ka eNOS mRNA aʻo ka hoʻonui ʻana i ka pane hilinaʻi NO i hoʻoulu ʻia e ka acetylcholine a me ka calcium ionophore, A23187. Eia kekahi, ke kāohi nei ka pitavastatin i ka hoʻoponopono ʻana i nā kahawai potassium-activated calcium ma o ka hoʻohaʻahaʻa ʻana i nā pae cholesterol i loko o nā cell.

Waihona

4°C, pale mai ka malamalama

*Ma ka solvent: -80°C, 6 mahina; -20°C, 1 mahina (pale mai ka malamalama)

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