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ʻO Rosuvastatin Calcium (BANM, JAN, USAN) ʻike ʻia ʻo Rosuvastatin ma US.a me kahi mea hoʻokūkū hoʻokūkū HMG-CoA reductase me kahi IC50 o 11 nM[1].Hoʻopaʻa ikaika ʻo Rosuvastatin Calcium i ke kanaka ether-a-go-go related gene (hERG) i kēia manawa me kahi IC50 o 195 nM, hoʻopaneʻe i ka repolarization cardiac, a no laila e hoʻolōʻihi ʻia ai ka lōʻihi o ka hana (APDs) a me ka hoʻoponopono ʻana i ka manawa QT (QTc) [2].Hoʻemi ʻo Rosuvastatin Calcium i ka hōʻike ʻana o ka hERG makua a me ka launa pū ʻana o ka protein haʻalulu wela 70 (Hsp70) me ka protein hERG.He mea maikaʻi loa ka Rosuvastatin Calcium i ka hoʻohaʻahaʻa ʻana i ka lipoprotein haʻahaʻa haʻahaʻa (LDL) cholesterol, triglycerides, a me nā pae protein C-reactive [3].

ʻIke hou aʻe e pili ana i nā hui inoa lāʻau: International Nonproprietary Names.

Hoʻolaha Nui: Aia ka ʻikepili honua ʻo Drugs.com ma ka hoʻokuʻu BETA.ʻO ia ke ʻano o ka hoʻomohala ʻana a loaʻa paha nā hewa.ʻAʻole i manaʻo ʻia ma ke ʻano he pani no ka ʻike a me ka hoʻoholo ʻana o kāu kauka, lāʻau lapaʻau a i ʻole nā ​​​​mea mālama ola kino ʻē aʻe.ʻAʻole pono e manaʻo ʻia he palekana, kūpono a maikaʻi paha ka hoʻohana ʻana i kekahi lāʻau lapaʻau ma kekahi ʻāina.E kūkākūkā me kāu kauka mālama ola ma mua o ka lawe ʻana i kekahi lāʻau lapaʻau.

I ka US, ʻo Rosuvastatin (rosuvastatin systemic) he lālā o ka papa lāʻau statins a hoʻohana ʻia e mālama i ka Atherosclerosis, High Cholesterol, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Elevated LDL, Hyperlipoproteinemia Type. IIb - LDL VLDL kiʻekiʻe, Hyperlipoproteinemia Type III - Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV - Kiʻekiʻe VLDL, Hypertriglyceridemia a me ka pale ʻana i ka maʻi cardiovascular.

Ka hope

He mea hoʻopaʻapaʻa koho a hoʻokūkū o HMG-CoA reductase, ʻo ia hoʻi he antilipemic.

Waihona

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