ʻO Pregabalin

Hōʻike Pōkole:

Ka inoa o API Hōʻike Hoakaka US DMF  EU DMF  CEP
ʻO Pregabalin Epilepsy / Neuralgia Ma-Hale / EP 22223 CEP2016-141

ʻIke kikoʻī

Nā huahana huahana

ʻIkepili Huahana

ʻAʻole Pregabalin kahi GABAA a i ʻole GABAB receptor agonist.
ʻO Pregabalin kahi gabapentinoid a hana i ka pāpā ʻana i kekahi mau kahawai calcium. ʻO kahi kikoʻī ia he lūlū o ka pūnaewele subaide α2δ kōkua o kekahi o nā kahawai kūkaʻi hilinaʻi uila (VDCCs), a ma laila e hana nei ma ke ʻano he mea kāohi i nā VDCC i loaʻa i ka subunit α2δ. Aia he ʻelua subunits α2δ e paʻa ana i ka lāʻau, α2δ-1 a me α2δ-2, a hōʻike like hoʻi ka pregabalin i ka pili like no (a no laila nele i ka selectivity ma waena o) kēia mau pūnaewele ʻelua. Koho ʻo Pregabalin i kāna paʻa ʻana i ka subunit VDCC α2δ. ʻOiai ʻo ka prababalin he analogic GABA ia, ʻaʻole ia e hoʻopili i nā mea loaʻa ʻo GABA, ʻaʻole ia e hoʻohuli iā GABA a i ʻole kahi agonist reseptor GABA i loko o vivo, a ʻaʻole ia e hoʻololi pono i ka halihali GABA a i ʻole ka metabolism. Eia nō naʻe, ua ʻike ʻia ka hana mua ʻana o kaababalin i ka hoʻonui ʻia ʻana o ka lāʻau i ka hōʻike o ka lolo o ka L-glutamic acid decarboxylase (GAD), ka ʻenemema i kuleana no ka synthesizing GABA, a no laila he mau hopena GABAergic ʻole ia e ka hoʻonui ʻana i nā pae GABA i ka lolo. ʻAʻohe hōʻike i kēia manawa e hoʻopili ʻia nā hopena o ka pregabalin e kekahi ʻano hana ʻē aʻe ma mua o ka pāpā ʻana o nā VDCC i loaʻa iā α2α. I kulike ai me ka pāpā ʻana o ka α2δ-1-i loko o nā VDCCs e ka wahine mua e like me ke kuleana no kona anticonvulsant, analgesic, a me nā hopena a me ka hopohopo.
ʻO nā endogenous α-amino acid L-leucine a me L-isoleucine, i like like me ka pregabalin a me nā gabapentinoids ʻē aʻe i ka hanana kemika, e ʻike ʻia nā ligands o ka α2δ VDCC subunit me ka pilina like me nā gabapentinoids (e like me, IC50 = 71 nM no L- isoleucine), a aia i loko o ka wai cerebrospinal o ke kanaka ma nā kikowaena micromolar (e like me, 12.9 μM no L-leucine, 4.8 μM no L-isoleucine). Ua manaʻo ʻia ʻo lākou ka ligands endogenous o ka subunit a hiki iā lākou ke hoʻokūkū hoʻokūkū i nā hopena o nā gabapentinoids. E like me, ʻo nā gabapentinoids e like me ka pregabalin a me ka gabapentin he mau nanomolar affinities no ka α2δ subunit, ʻo ko lākou mau mana i loko o ka vivo aia i ka pae micromolar haʻahaʻa, a ʻo ka hoʻokūkū no ka hoʻopaʻa ʻana e nā endogenous L-amino acid i ʻōlelo ʻia e pili ana i kēia pilikia.

Ua loaʻa iā Pregabalin ka loaʻa ʻana o 6 ka nui ʻoi aku ka pilina ma mua o ka gabapentin no nā VDCC i loaʻa i ka subunit i loko o hoʻokahi noiʻi. Eia nō naʻe, ua loaʻa kahi noiʻi ʻē aʻe he like like ka pili o ka pregabalin a me ka gabapentin no ka subunit recondinant α2δ-1 (Ki = 32 nM a me 40 nM). I kēlā me kēia hihia, ʻo ka pregabalin ʻo 2 a 4 mau manawa ʻoi aku ka ikaika ma mua o ka gabapentin ma ke ʻano he analgesic a, i nā holoholona, ​​ʻike ʻia he 3 a 10 mau manawa ʻoi aku ka ikaika ma mua o gabapentin ma ke ʻano he anticonvulsant.

CERTIFICATE

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

KA MANAWAI ANA

Quality management1

Palapala Noi 18 Nā papahana loiloi e like me ka Consistency i ʻae ʻia 4, a 6 ke ʻae ʻia nei nā papahana.

Quality management2

Ua hoʻokumu ʻia ka ʻōnaehana hoʻokele kūlana kiʻekiʻe kiʻekiʻe loa no ke kūʻai aku.

Quality management3

Holo ka nānā ʻana i ka maikaʻi ma waena o ke ola holoʻokoʻa o ka huahana e hōʻoia i ka maikaʻi a me ka hopena therapeutic. 

Quality management4

Kākoʻo ka ʻoihana Hoʻokele ʻoihana ʻoihana i nā koi maikaʻi i ka wā o ka noi a me ke kau inoa.

MANAGEMENT HUA

cpf5
cpf6

Kōleka Packaging ʻōmole Korea

cpf7
cpf8

ʻO ka laina Packaging ʻōmole ʻo Taiwan CVC

cpf9
cpf10

ʻO ka laina Packaging Papa CAM Italia

cpf11

Mīkini Pīkī Fette Kelemania

cpf12

ʻO Iapana Viswill Tablet Detector

cpf14-1

Rumi Nahenahe DCS

HOA HOA

ʻO ke alu like ʻana me ka honua
International cooperation
Hana kūloko
Domestic cooperation

  • Kekahi:
  • Aʻe:

  • Kākau i kāu leka ma aneʻi a hoʻouna iā mākou

    Nā huahana huahana