Captopril
wehewehe
ʻO Captopril (SQ-14534) he mea hoʻokūkū ikaika, hoʻokūkū hoʻokūkū o ka angiotensin-converting enzyme (ACE).
In Vitro
Ua hōʻike ʻia ʻo Captopril (SQ-14534) e like me ka maʻi maʻi a me nā pōmaikaʻi o ka make me nā diuretics a me nā beta-blockers i nā maʻi hypertension. Ua hōʻike ʻia ʻo Captopril (SQ-14534) e lohi i ka piʻi ʻana o ka nephropathy maʻi maʻi, a ʻo ka enalapril a me lisinopril e pale i ka ulu ʻana o ka nephropathy i nā maʻi normoalbuminuric me ka maʻi diabetes. Aia ka ratio like o ka cis a me ka moku'āina trans o Captopril (SQ-14534) i ka hoʻonā a ke koho nei ka enzyme i ka moku'āina trans o ka mea hoʻopaneʻe e hōʻike ana i ka hoʻohui ʻana a me ka stereoelectronic me kona ʻāpana paʻa substrate[2].
ʻAʻole ʻo MCE i hōʻoia kūʻokoʻa i ka pololei o kēia mau ʻano. No ka kuhikuhi wale no.
Hoao Hoao
| Helu NCT | Kākoʻo | Kūlana | lā hoʻomaka | Māhele |
| NCT03179163 | Ke Kula Nui ʻo Penn State|National Heart, Lung, and Blood Institute (NHLBI) | ʻO ke koko kiʻekiʻe, Pono | Iulai 20, 2016 | Māhele 1|Mahele 2 |
| NCT03660293 | Kulanui ʻo Tanta | ʻO ka maʻi diabetes mellitus, ʻano 1 | ʻApelila 1, 2017 | Pili ʻole |
| NCT03147092 | Centro Neurológico de Pesquisa a me Reabiitação, Palakila | ʻO ke kiʻekiʻe|ke koko | Pepeluali 1, 2018 | Māhele mua 1 |
| NCT00252317 | Rigshopitalet, Denemaka | Aortic Stenosis | Nowemapa 2005 | Māhele 4 |
| NCT02217852 | Halemai Kina Komohana | Ka maʻi kiʻekiʻe | ʻAukake 2014 | Māhele 4 |
| NCT01626469 | ʻO Brigham a me ka Halemai Wahine | ʻO ka maʻi diabetes type 2 | Mei 2012 | Māhele 1|Mahele 2 |
| NCT00391846 | AstraZeneca | Puuwai Puuwai|Ventricular Dysfunction, Left | ʻOkakopa 2006 | Māhele 4 |
| NCT00240656 | Hebei Medical University | ʻO ke kiʻekiʻe kiʻekiʻe, ka Pulmonary | ʻOkakopa 2005 | Māhele 1 |
| NCT00086723 | Ke Kulanui ʻĀkau Komohana|National Cancer Institute (NCI) | ʻAʻole i hōʻike ʻia i ke kino paʻa o nā mākua, Kūkākūkā kikoʻī | Iulai 2003 | Māhele 1|Mahele 2 |
| NCT00663949 | Shiraz University of Medical Sciences | ʻO Nephropathy maʻi maʻi | Pepeluali 2006 | Māhele 2|Mahele 3 |
| NCT01437371 | Halemai Kula Nui, Clermont-Ferrand|Servier|LivaNova | Puuwai Puuwai | ʻAukake 2011 | Māhele 3 |
| NCT04288700 | Ke Kulanui ʻo Ain Shams | Hemangioma keiki | ʻOkakopa 1, 2019 | Māhele 4 |
| NCT00223717 | Ke Kulanui ʻo Vanderbilt|Ke Kula Nui ʻo Vanderbilt | Ka maʻi kiʻekiʻe | Ianuali 2001 | Māhele 1 |
| NCT02770378 | Ke Kulanui o Ulm|Hoʻomaʻi maʻi maʻi hilinaʻi|Pu kālā Anticancer, Belgium | ʻO Glioblastoma | Nowemapa 2016 | Māhele 1|Mahele 2 |
| NCT01761916 | Instituto Materno Infantil Prof. Fernando Figueira | Preeclampsia | Ianuali 2013 | Māhele 4 |
| NCT01545479 | Instituto de Cardiologia do Rio Grande do Sul | Ma'i Renal | Ianuali 2010 | Māhele 4 |
| NCT00935805 | Hospital de Clinicas de Porto Alegre|Conselho Nacional de Desenvolvimento Científico and Tecnológico|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Palakila | ʻO ka maʻi maʻi ʻaʻai|ʻaʻa koko | Iulai 2006 |
|
| NCT00742040 | Ka Halemai no na keiki mai | ʻO ka maʻi puʻuwai | ʻAukake 2008 | Māhele 2 |
| NCT03613506 | Ke Kulanui ʻo Wuhan | ʻO ka hopena ʻaoʻao Radiotherapy|Ka lawe ʻana i ka Captopril | ʻOkakopa 25, 2018 | Māhele 2 |
| NCT00004230 | Ke Kulanui ʻĀkau Komohana|National Cancer Institute (NCI) | Ka ma'i 'a'ai | ʻOkakopa 1999 | Māhele 3 |
| NCT00660309 | Novartis | ʻO ka maʻi diabetes type 2 | ʻApelila 2008 | Māhele 4 |
| NCT00292162 | NHS Greater Glasgow a me Clyde | Hoʻopau ʻia ka naʻau|Atrial Fibrillation | Ianuali 2007 | Pili ʻole |
| NCT01271478 | Coordination de Investigación en Salud, Mekiko | ʻAha|Ka maʻi Renal pae hope | ʻAukake 2009 | Māhele 4 |
| NCT04193137 | Ke Kulanui Lapaʻau ʻo Chongqing | Aldosteronism kumu mua | Nowemapa 30, 2019 |
|
| NCT00155064 | Halema'i Kula Nui o Taiwan | Hyperaldosteronism | Iulai 2002 | Māhele 4 |
| NCT01292694 | Ke Kulanui ʻo Vanderbilt|Ke Kula Nui ʻo Vanderbilt | ʻO ke kiʻekiʻe nui|Pure Autonomic Failure|Multiple System Atrophy | Malaki 2011 | Māhele 1 |
| NCT00917345 | Halema'i Kula Nui o Taiwan|Novartis | Aldosteronism kumu mua | Ianuali 2008 |
|
| NCT00077064 | Hui Pūʻulu Hoʻomaʻamaʻa Radiation Therapy Oncology|National Cancer Institute (NCI)|NRG Oncology | Ka maʻi maʻi ʻāʻī|Pulmonary Complications|Radiation Fibrosis | Iune 2003 | Māhele 2 |
Waihona
| Pauda | -20°C | 3 makahiki |
| 4°C | 2 makahiki | |
| I ka solvent | -80°C | 6 mahina |
| -20°C | 1 mahina |
ʻO ke kinona
Manaʻo18Nā papahana Loiloi Kūlike Kūlike i ʻae ʻia4, a6apono ʻia nā papahana.
Ua hoʻokumu ka ʻōnaehana hoʻokele maikaʻi honua kiʻekiʻe i ke kumu kūʻai.
Holo ka nānā ʻana i ka maikaʻi ma ke ola holoʻokoʻa o ka huahana e hōʻoia i ka maikaʻi a me ka hopena therapeutic.
Kākoʻo ka hui ʻoihana Regulatory Affairs i nā koi maikaʻi i ka wā o ke noi a me ke kākau inoa ʻana.
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