Nā mea hana a me nā mea kūʻai aku Kina Chlorothiazide

Chlorothiazide

Hōʻike Pōkole:

Ka inoa o API	Hōʻike	Hoakaka	US DMF	EU DMF	CEP
Chlorothiazide	ʻO Diuretics	USP / EP

E hoʻouna leka uila iā mākou

ʻIke kikoʻī

Nā huahana huahana

ʻIkepili Huahana

Papa kāʻei kua

He mea kāohi ʻo Chlorothiazide i ka anhydrase kalapona a ʻoi aku ka liʻiliʻi o ka ikaika ma mua o ka acetazolamide. Ua hōʻike ʻia kēia hui e ālai i ka reabsorption o nā iona sodium a me chloride.

Wehewehe

ʻO Chlorothiazide kahi diuretic a me antihypertensive. (IC50 = 3.8 mM) Pahuhopu: ʻO kekahi Chlorothiazide sodium (Diuril) kahi diuretic i hoʻohana ʻia i loko o ka haukapila hoʻonohonoho a i ʻole no ka hoʻohana pilikino ʻana e hoʻokele i ka nui o ka wai e pili ana me ka puʻuwai puʻuwai congestive. Hoʻohana ʻia ia ma ke ʻano he antihypertensive. Lawe pinepine ʻia i ka pila pila, lawe pinepine ʻia ia ma ka waha hoʻokahi a i ʻole ʻelua mau manawa i ka lā. I ka hoʻonohonoho ICU, hāʻawi ʻia ʻo chlorothiazide i diurese kahi mea maʻi ma ka hoʻohui o ka furosemide (Lasix). Ke hana nei i kahi ʻano kaʻawale ma mua o ka furosemide, a komo ʻoluʻolu e like me kahi hoʻomaha hoʻomaha i lawelawe ʻia ma o ka tube nasogastric (NG tube), hiki i nā lāʻau ʻelua ke hoʻoikaika i kekahi i kekahi.

Hoʻokolohua Lapaʻau

Helu NCT	Kākoʻo	Kūlana	Lā Hoʻomaka	ʻĀpana
NCT03574857	Kulanui o Virginia	Ka Puʻuwai puʻuwai \| Hōʻeha puʻuwai me ka hoʻoliʻiliʻi hoʻoliʻiliʻi \| ʻO ka puʻuwai puʻuwai	Iune 2018	Pae 4
NCT02546583	Ke Kulanuiʻo Yale \| National Heart, Lung, a me Blood Institute (NHLBI)	Hoka Puʻuwai	ʻAukake 2015	Pili 'ole
NCT02606253	Kula Nui Vanderbilt \| Hale Waihona Lapaʻau Kula ʻo Vanderbilt	Hoka Puʻuwai	Pepeluali 2016	Pae 4
NCT00004360	National Center for Research Resources (NCRR) \| Ke Kulanui o Northwestern \| Office of Rare Diseases (ORD)	ʻO Diabetes Insipidus, nephrogenic	Kepakemapa 1995
NCT00000484	National Heart, Lung, and Blood Institute (NHLBI)	Nā maʻi maʻi puʻuwai \| Nā maʻi puʻuwai \| Hypertension \| Nā maʻi Vascular	ʻApelila 1966	Kau 3