ʻO Kina Baloxavir Marboxil 1985606-14-1 nā mea hana a me nā mea hoʻolako

Baloxavir Marboxil 1985606-14-1

ʻO ka wehewehe pōkole:

Ka inoa o ka API	Hōʻike	Mea hana hou	Lā Hoʻopau Patent (ʻAmelika)
Baloxavir Marboxil 1985606-14-1	Influenza	Shionogi & Roche	Sep.21,2031

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

NUI HUA

Kāpae

He lāʻau antiviral ʻo Baloxavir marboxil a he mea hoʻopale endonuclease. I nā ʻiole a me nā monkey, ʻoi aku ka haʻahaʻa o ke koko o ka lāʻau lapaʻau ma mua o ka liʻiliʻi liʻiliʻi i ʻike ʻia i ka hoʻokele waha o ka lāʻau. I loko o nā ʻano maʻi maʻi preclinical A a me B (me nā maʻi i kū i nā lāʻau antiviral e kū nei), he hopena ko Baloxavir marboxil.

Na Waiwai Kemika

Waihona	E mālama i ka -20°C
M.Wt	571.55
Cas No.	1985606-14-1
Kumukumu	C27H23F2N3O7S
Nā huaʻōlelo like	S-033188
Ka hoʻoheheʻe	Hiki ke hoʻoheheʻe ʻia ma DMSO
Inoa Kimia	(((R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-6,8-dioxo-3,4,6,8 ,12,12a-hexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl)oxy)methyl methyl carbonate
SDF	Hoʻoiho iā SDF
KANAKA MANAKA	O=C1C=CN(N([C@]2(N(C3=O)CCOC2)[H])[C@H]4C5=CC=C(C(F)=C5CSC6=CC=CC=C46) F)C3=C1OCOC(OC)=O
Kūlana Hoʻouna	Haʻina hāpana loiloi: moku me ka hau polū. Loaʻa nā nui ʻē aʻe: moku me RT, a i ʻole hau polū ma ke noi.
Nā ʻōlelo aʻoaʻo maʻamau	No ka loaʻa ʻana o kahi solubility kiʻekiʻe, e ʻoluʻolu e hoʻomaʻamaʻa i ka paipu ma 37 ° C a lulu i loko o ka ʻauʻau ultrasonic no kekahi manawa. Hiki ke mālama ʻia ka hoʻonā waiwai ma lalo o -20°C no kekahi mau mahina.