Agomelatine
Ka hope
ʻO Agomelatine kahi agonist o ka melatonin receptors a me kahi mea kū'ē i ka serotonin 5-HT2C receptor me nā waiwai Ki o 0.062nM a me 0.268nM a me IC50 waiwai o 0.27μM, no MT1, MT2 a me 5-HT2C [1].
He antidepressant kū hoʻokahi ʻo Agomelatine a ua hoʻomohala ʻia no ka mālama ʻana i ka maʻi depressive nui (MDD).Ua koho ʻo Agomelatine i ka 5-HT2C.Hōʻike ia i nā haʻahaʻa haʻahaʻa i ka cloned kanaka 5-HT2A a me 5-HT1A.No nā melatonin receptors, hōʻike ʻo agomelatine i nā pili like i ka cloned kanaka MT1 a me MT2 me nā helu Ki o 0.09nM a me 0.263nM, kēlā me kēia.Ma nā haʻawina in vivo, ʻo agomelatine ke kumu o ka piʻi ʻana o nā pae dopamine a me nā noradrenaline ma o ka pale ʻana i ka hoʻokomo inhibitory o 5-HT2C.Eia kekahi, ʻo ka hoʻokele ʻana o agomelatine e kūʻē i ka emi ʻana o ke koʻikoʻi i ka hoʻohana ʻana i ka sucrose i kahi ʻano ʻiole o ke kaumaha.Ma waho aʻe o kēlā, hoʻohana ʻo agomelatine i ka hoʻohaʻahaʻa ʻana i ka manaʻo hopohopo i loko o kahi ʻano rodent o ka hopohopo [1].
Kuhikuhi:
[1] Zupancic M, Guilleminault C. Agomelatine.Nā lāʻau lapaʻau CNS, 2006, 20 (12): 981-992.
ʻO ke kinona
Manaʻo18Nā papahana Loiloi Kūlike Kūlike i ʻae ʻia4, a6nā papahana ma lalo o ka ʻae ʻia.
Ua hoʻokumu ka ʻōnaehana hoʻokele maikaʻi honua kiʻekiʻe i ke kumu kūʻai.
Holo ka nānā ʻana i ka maikaʻi ma ke ola holoʻokoʻa o ka huahana e hōʻoia i ka maikaʻi a me ka hopena therapeutic.
Kākoʻo ka hui ʻoihana Regulatory Affairs i nā koi maikaʻi i ka wā o ke noi a me ke kau inoa ʻana.
Kolea Countec Bottled Packaging Line
ʻO Taiwan CVC Bottled Packaging Line
ʻO Italia CAM Board Packaging Line
Mekini Fette Compacting German
ʻO Iapana Viswill Tablet ʻIke
Keena Mana DCS
