Kāpae

ʻO Tofacitinib citrate, ka mea i kapa ʻia ʻo CP-690550 citrate, he mea paʻa ikaika o janus kinase 3 (JAK3), he tyrosine kinase hematopoetic cell-restricted tyrosine kinase i komo i ka transduction signal e hoʻoponopono ana i ke ola lymphocyte, proliferation, differentiation, a me apoptosis. ʻO ka inhibition he JAK3 kikoʻī me kahi koho 1000-fold ma mua o nā kinases ʻohana non-JAK. Ma waho aʻe o ka pale ʻana iā JAKS (IC50 = 1 nM), ʻo tofacitinib citrate hoʻi e kāohi i ka janus kinase 2 (JAK2) a me ka janus kinase 1 (JAK1) me ka 20- a me 100-fold ka liʻiliʻi o ka potency. Eia naʻe, i loko o kahi noiʻi hou, ua hōʻike ʻia nā pili pili (Ki) o tofacitinib citrate e pili ana iā JAK1, JAK2, a me JAK3 he 1.6 nM, 21.7 nM, a me 6.5 nM.

Kuhikuhi

Lalitha Vijayakrishnan, R. Venkataramanan a me Palak Gulati. Ka mālama ʻana i ka mumū me ka janus kinase inhibitor CP-690,550. Nā Kūlana i ka ʻepekema Pharmacological 2011: 32 (1); 25-34

Huahana Huahana

• 1. Panagi I, Jennings E, et al. "Hoʻololi ʻo Salmonella Effector SteE i ka Mammalian Serine/Threonine Kinase GSK3 i loko o kahi Tyrosine Kinase e kuhikuhi i ka Macrophage Polarization." Pūnaewele Host Microbe. 2020;27(1):41–53.e6. PMID:31862381
• 2. McInnes IB, Byers NL, et al. "ʻO ka hoʻohālikelike o ka baricitinib, upadacitinib, a me tofacitinib i hoʻoponopono i ka hoʻoponopono o ka cytokine hōʻailona i nā subpopulations leukocyte kanaka." ʻO ka Arthritis Res Ther. 2019 ʻAukake 2;21(1):183. PMID:31375130
• 3. Liu S, Verma M, et al. "Ke kū'ēʻana o ka steroid o nā pūnaewele lymphoid maʻamau o ke ala ea mai nā maʻi me ka hānō koʻikoʻi: Ke kuleana o ka thymic stromal lymphopoietin." J Allergy Clin Immunol. 2018 Ian;141(1):257-268.e6. PMID:28433687
• 4. Zheng, Lufeng, et al. "ʻO ka 3' UTR o ka pseudogene CYP4Z2P e hoʻoikaika i ka angiogenesis tumor i ka maʻi kanesa o ka umauma ma o ka hana ʻana he ceRNA no CYP4Z1." Ka noiʻi a me ka mālama ʻana i ka maʻi maʻi umauma (2015): 1-14. PMID:25701119

wehewehe

ʻO Tofacitinib citrate kahi mea hoʻopaneʻe JAK1 / 2/3 waha me IC50s o 1, 20, a me 112 nM. Loaʻa i ka Tofacitinib citrate nā hana antibacterial, antifungal a me antiviral.

Waihona

4°C, pale mai ka malamalama

*Ma ka solvent: -80°C, 6 mahina; -20°C, 1 mahina (pale mai ka malamalama)

ʻO ke kinona

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