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ʻO Rosuvastatin Calcium (BANM, JAN, USAN) ʻike ʻia ʻo Rosuvastatin ma US. a me ka mea hoʻokūkū hoʻokūkū HMG-CoA reductase me kahi IC50 o 11 nM[1]. Hoʻopaʻa ikaika ʻo Rosuvastatin Calcium i ke kanaka ether-a-go-go related gene (hERG) i kēia manawa me kahi IC50 o 195 nM, hoʻopaneʻe i ka repolarization cardiac, a no laila e hoʻolōʻihi ai i nā hana hiki ke hana (APDs) a hoʻoponopono i ka wā QT interval (QTc) [2]. Hoʻemi ʻo Rosuvastatin Calcium i ka hōʻike ʻana o ka hERG makua a me ka hoʻopili ʻana o ka protein haʻalulu wela 70 (Hsp70) me ka protein hERG. ʻO Rosuvastatin Calcium ka mea maikaʻi loa i ka hoʻohaʻahaʻa ʻana i ka lipoprotein haʻahaʻa haʻahaʻa (LDL) cholesterol, triglycerides, a me nā pae protein C-reactive [3].

ʻIke hou aʻe e pili ana i nā hui inoa lāʻau: International Nonproprietary Names.

Hoʻolaha Nui: Aia ka ʻikepili honua ʻo Drugs.com ma ka hoʻokuʻu BETA. ʻO ia ke ʻano o ka hoʻomohala ʻia ʻana a loaʻa paha nā hemahema. ʻAʻole i manaʻo ʻia ma ke ʻano he pani no ka ʻike a me ka hoʻoholo ʻana o kāu kauka, lāʻau lapaʻau a i ʻole nā ​​​​mea mālama ola kino ʻē aʻe. ʻAʻole pono e manaʻo ʻia he palekana, kūpono a kūpono paha ka hoʻohana ʻana i kekahi lāʻau lapaʻau ma kekahi ʻāina. E kūkākūkā me kāu kauka mālama ola ma mua o ka lawe ʻana i kekahi lāʻau lapaʻau.

I ka US, ʻo Rosuvastatin (rosuvastatin systemic) he lālā ia o ka papa lāʻau statins a hoʻohana ʻia e mālama i ka Atherosclerosis, High Cholesterol, High Cholesterol - Familial Heterozygous, High Cholesterol - Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Elevated LDL, Hyperlipoproteinemia Type. IIb - Hoʻokiʻekiʻe LDL VLDL, Hyperlipoproteinemia Type III - Hoʻokiʻekiʻe beta-VLDL IDL, Hyperlipoproteinemia Type IV - Hoʻokiʻekiʻe VLDL, Hypertriglyceridemia a me ka pale ʻana i ka maʻi cardiovascular.

Kāpae

He mea hoʻokūkū hoʻokūkū hoʻokūkū o HMG-CoA reductase, ʻo ia hoʻi he antilipemic.

Waihona

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