ʻO ka Pomalidomide, i ʻike mua ʻia ʻo CC-4047 a i ʻole actimid, he mole immunomodulatory ikaika e hōʻike ana i ka hana antineoplastic no ka mālama ʻana i nā maʻi maʻi hematological, ʻoi aku ka relapsed a refractory multiple myeloma (MM). Ma ke ʻano he derivative o ka thalidomide, ʻo ka pomalidomide he ʻano kemika like me ka thalidomide koe wale nō ka hoʻohui ʻana o ʻelua pūʻulu oxo i ke apo phthaloyl a me kahi hui amino ma ke kūlana ʻehā. ʻO ka mea maʻamau, ma ke ʻano he immunomodulatory mole, hōʻike ka pomalidomide i ka hana antitumor ma o kahi ʻano o ka pale ʻana i ka microenvironment tumo ma o ka modulation o nā cytokines kākoʻo tumor (TNF-α, IL-6, IL-8 a me VEGF), hoʻoponopono pololei i nā hana koʻikoʻi o ka ʻōpū. nā pūnaewele, a me ke kākoʻo ʻana mai nā pūnaewele hoʻokipa non-immune.

Hoʻohana ʻia ka Pomalidomide no ka mālama ʻana i ka myeloma lehulehu (ka maʻi maʻi mai ka maʻi koko holomua). Hāʻawi pinepine ʻia ka Pomalidomide ma hope o ʻelua mau lāʻau ʻē aʻe i hoʻāʻo ʻia me ka ʻole o ka kūleʻa.

Hoʻohana pū ʻia ka Pomalidomide no ka mālama ʻana i ka maʻi maʻi Kaposi pili i ka AIDS inā ʻaʻole i hana nā lāʻau ʻē aʻe a i ʻole i pau ka hana. Hiki ke hoʻohana ʻia ka pomalidomide e mālama iā Kaposi Sarcoma i nā pākekeHIV-ʻino.

Loaʻa ka Pomalidomide mai kahi lāʻau lapaʻau i hōʻoia ʻia ma lalo o kahi papahana kūikawā. Pono ʻoe e hoʻopaʻa inoa i ka papahana a ʻae e hoʻohanahoʻomalu hānauana e like me ka makemake.

Hiki ke hoʻohana ʻia ka Pomalidomide no nā kumu ʻaʻole i helu ʻia ma kēia alakaʻi lāʻau lapaʻau.

Hiki i ka Pomalidomide ke hoʻoulu i nā pōʻino hānau koʻikoʻi a i ʻole ka make ʻana o kahi pēpē inā lawe ka makuahine a makua kāne paha i ka pomalidomide i ka wā o ka hāpai ʻana a i ka wā hāpai. Hiki i ka pomalidomide hoʻokahi ke hoʻopōʻino i nā lima a me nā wāwae o ke pēpē, nā iwi, nā pepeiao, nā maka, ka maka, a me ka puʻuwai. Mai hoʻohana i ka pomalidomide inā hāpai ʻoe. E haʻi koke i kāu kauka inā lohi kou manawa i ka lawe ʻana i ka pomalidomide.