ʻO Doxycycline Hyclate
Ka hope
ʻO ka Doxycycline hyclate kahi lāʻau lapaʻau [1].
ʻO ka Doxycycline hyclate kahi hua o ka tetracycline a loaʻa iā ia nā hana anti-inflammatory a me antimicrobial.Kāohi ʻo Doxycycline i ka hoʻopiʻi hou ʻana o ka maʻi dengue i loko o ka vitro me kahi ʻano hilinaʻi wela.ʻO ka waiwai IC50 he 52.3μM ma 37°C a me 26.7μM ma 40°C.Kāohi ia i ka maʻi dengue ma o ke kāohi ʻana i ka protease serine NS2B-NS3 o ka maʻi.Hoʻemi ʻo 60μM doxycycline i ka CPE o nā mea i hoʻopili ʻia e DNEV2 [1].
ʻIke ʻia ʻo Doxycycline he mea hoʻokae o MMP.Hoʻemi ka lāʻau Doxycycline i nā pae MMP-8 a me -9 a keʻakeʻa i ka hōʻike ʻana o ka kiko MMP-2 a me MMP-9.Eia kekahi, ʻo ka mālama ʻana me ka doxycycline e hoʻemi nui i ka ulu ʻana o nā aneurysms intracranial.Ua hōʻike pū ʻia ʻo Doxycycline he lāʻau anti-inflammatory ma muli o kāna kaohi ʻana i nā metalloproteinases matrix.Eia kekahi, loaʻa i ka doxycycline ka hana antimalarial potent me ka waiwai IC50 o 320nM ma 96h in vitro [2, 3].
Kuhikuhi:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. ʻO ka hopena inhibitory o doxycycline e kū'ē i ka hoʻopiʻi houʻana o ka maʻi dengue i loko o ka vitro.Arch Virol.2014 Apr;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Ke kuleana o ka matrix metalloproteinases (MMPs) a me ka MMP inhibitors ma intracranial aneurysms: he ʻatikala loiloi.Med J Islam Repub Iran.2013 Nov;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.In vitro a in vivo antimalarial efficacies o optimized tetracyclines.Nā ʻĀpana Antimicrob Chemother.2013 Iulai;57(7):3131-6.
wehewehe
ʻO Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), he lāʻau'alopelo, he mea hoʻoikaika waha a me ka mea hoʻopaneʻe metalloproteinase (MMP) ākea [1].
ʻO ka hoʻokolohua lapaʻau
| Helu NCT | Kākoʻo | Kūlana | Lā Hoʻomaka | Māhele |
| NCT00246324 | ʻO Louisiana State University Health Science Center Shreveport|Biogen | ʻO ka maʻi maʻi maʻi maʻi | Kekemapa 2003 | Māhele 4 |
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| NCT00243893 | Ke Kulanui o Kaleponi, Kapalakiko|National Institute of Neurological Disorders and Stroke (NINDS) | Aneurysms|Nā ʻano ʻino | Iulai 2004 | Māhele 1 |
| NCT00126399 | ʻO CollaGenex Pharmaceuticals | ʻO Rosacea | Iune 2004 | Māhele 3 |
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| NCT00177333 | Kulanui o Pittsburgh | Hoʻokomo ʻia, Hoʻoulu ʻia|Ka luaʻi | Kepakemapa 2005 | Māhele 4 |
| NCT00007735 | Keʻena ʻOihana ʻAmelika Hui Pū ʻIa|Pfizer|Keʻena ʻOihana ʻAmelika Hui Pū ʻIa|Keʻena ʻOihana ʻImi a Hoʻomohala ʻo VA | ʻO Persian Gulf Syndrome|Mycoplasma Infections | Ianuali 1999 | Māhele 3 |
| NCT00351273 | Ke Kulanui o South Florida|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Arthritis, Reactive|Reiter Disease | Mei 2006 | Māhele 3 |
| NCT00469261 | Halemai Careggi | ʻO ka Myocardial Infarction|Ka Hoʻoponopono Hou ʻana o Ventricular Hema | Mei 2007 | Māhele 2 |
| NCT00547170 | Ke Kulanui o Pittsburgh|Hakapila ʻo Tu Du | Endometritis | Ianuali 2007 | Māhele 4 |
| NCT01475708 | Ke Kulanui Lapaʻau Ljubljana | ʻO Lyme Borreliosis | Mei 2011 |
|
| NCT01368341 | Morten Lindbaek|Ke Kula Nui o Norewai o ke Ola Aupuni|Sorlandet Hospital HF|Ke Kulanui o Ola Ola Noweke|Ke Kulanui o Oslo | Erythema Migrans|Erythema Chronicum Migrans|Borreliosis|Ma'i Lyme|Ma'i Lyme Mua | Iune 2011 | Māhele 4 |
| NCT02538224 | Ke Kulanui ʻo Islam Azad, Tehran | Periodontitis mau | Iulai 2013 | Māhele 2|Mahele 3 |
| NCT00066027 | Ke Kulanui o Nebraska|National Institute of Dental and Craniofacial Research (NIDCR) | Periodontitis | Iune 2002 | Māhele 3 |
| NCT00376493 | Halemai de Clinicas de Porto Alegre | ʻO ka hoʻohemo ʻana o Septic | Mei 2006 | Māhele 4 |
| NCT03448731 | Fundacion CRIS de Investigación para Vencer el Cáncer|Amgen|Apices Soluciones SL | ʻili ʻona | Mei 10, 2018 | Māhele 2 |
| NCT00989742 | Kulanui o Nottingham | Lymphangioleiomyomatosis|Tuberous Sclerosis | Iulai 2009 | Māhele 4 |
| NCT01438515 | Pūnaewele Ola Horizon | ʻO Staphylococcus Aureus kū i ka methicillin | ʻAukake 2008 | Pili 'ole |
| NCT02929121 | ʻO ka Task Force for Global Health|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Ianuali 15, 2019 | Māhele 3 |
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| NCT00942006 | Ke Kulanui Lapaʻau Ljubljana | Hoʻopiʻi ʻia ʻo Lyme Neuroborreliosis mua | Iulai 2009 | Pili 'ole |
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| NCT00000938 | National Institute of Allergy and Infectious Diseases (NIAID) | ʻO ka maʻi Lyme | Māhele 3 | |
| NCT01398072 | Ke Kula Nui, Lādana|Royal Free Hampstead NHS Trust|University of Cambridge|National Institute for Health Research, United Kingdom | ʻO ka maʻi maʻi ʻāʻī ʻāʻī (COPD). | Kekemapa 2011 | Māhele 3 |
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| NCT01744093 | Weill Medical College o Cornell University|National Heart, Lung, and Blood Institute (NHLBI) | HIV|Ma'i Pukolu Ho'opa'a Mau (COPD)|Emphysema | Iulai 17, 2014 | Pili 'ole |
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| NCT01474590 | Galderma | ʻAneʻe | Nowemapa 2011 | Māhele 3 |
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| NCT01010295 | Pūʻulu Hoʻonaʻauao ʻo International Extranodal Lymphoma (IELSG) | ʻO Lymphoma Non-Hodgkin | Kepakemapa 2006 | Māhele 2 |
| NCT00775918 | ʻO Ranbaxy Laboratories Limited|Ranbaxy Inc. | Ola ola | Iune 2005 | Pili 'ole |
| NCT04050540 | Ke Kulanui o Wakinekona|Kenya Medical Research Institute|Kenya National AIDS & STI Control Program|University of California, San Francisco|National Institute of Allergy and Infectious Diseases (NIAID) | Nā maʻi HIV|HIV+AIDS|Neisseria Gonorrheae maʻi|Chlamydia Trachomatis maʻi|Maʻi Syphilis | Pepeluali 5, 2020 | Māhele 4 |
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| NCT00001101 | National Institute of Allergy and Infectious Diseases (NIAID) | ʻO ka maʻi Lyme | Māhele 3 | |
| NCT00340691 | National Institute of Allergy and Infectious Diseases (NIAID)|Na National Institute of Health Clinical Center (CC) | Mansonella Perstans Infection|Mp Microfilaremia | Kekemapa 6, 2004 | Māhele 2 |
| NCT01112059 | Ke Kulanui o Alabama ma Birmingham|Cystic Fibrosis Foundation | Cystic Fibrosis | Nowemapa 2008 | Pili 'ole |
| NCT00652704 | Par Pharmaceutical, Inc.|Anapharm | No ka hoʻoholo ʻana i ka bioequivalence ma lalo o nā kūlana Fed | Iulai 1999 | Māhele 1 |
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| NCT02564471 | Ke Kulanui Mokuʻāina o New York - Ke Kulanui Lapaʻau Upstate|Walter Reed Army Institute of Research (WRAIR)|Kansas State University | Rabies | ʻApelila 2016 | Māhele 4 |
| NCT04206631 | Kula Nui o Indonesia | ʻAneʻe vulgaris | ʻApelila 1, 2015 | Māhele 1 |
| NCT03956446 | Ke Kula Nui Lapaʻau Ljubljana|Ke Kula Lapaʻau o Ljubljana, Slovenia | Tick Borne Encephalitis | Kepakemapa 1, 2014 | Pili 'ole |
| NCT03960411 | Felix Chikita Fredy, MD|National Cardiovascular Center Harapan Kita Hospital Indonesia|Indonesia University | ST Elevation Myocardial Infarction|Papa Imua o ka Myocardial Infarction|Haʻule Puʻuwai|Remodeling, Ventricular | Mei 25, 2019 | Māhele 3 |
| NCT00322465 | National Institute of Allergy and Infectious Diseases (NIAID) | Urethritis | Nowemapa 2006 | Māhele 2 |
| NCT01375491 | Ke Kulanui o Kaleponi, San Diego|Ruth L. Kirschstein National Research Service Award|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Center for Research Resources (NCRR) | ʻAno maʻi maʻi diabetes 2|Obesity | ʻOkakopa 2009 | Māhele 4 |
| NCT03478436 | Ke Kulanui Lapaʻau o Vienna|Dr.ʻO Reddy's Laboratories Limited | ʻO Rosacea | Iulai 2016 | Māhele 1 |
| NCT01207739 | Ke Kulanui o Radboud|Sint Maartenskliniek|ZonMw: ʻO ka Hui Holani no ka ʻImi Ola a me ka Hoʻomohala ʻana | Ka ma'i Lyme|Ma'i Borrelia | Kepakemapa 2010 | Māhele 4 |
| NCT00939562 | Pfizer | Ka maʻi bacteria | Nowemapa 2008 | Māhele 4 |
| NCT03608774 | National Institute of Allergy and Infectious Diseases (NIAID) | Ma'i Chlamydia Anal | Iune 26, 2018 | Māhele 4 |
| NCT02281643 | Kwame Nkrumah University of Science and Technology|University of Bonn|Heinrich-Heine University, Duesseldorf | Mansonella Perstans Infection|Buruli Ulcer|Tuberculosis|Co-infection | ʻOkakopa 2014 | Māhele 2 |
| NCT00066066 | ʻO ka Forsyth Institute|National Institute of Dental and Craniofacial Research (NIDCR) | Periodontitis|Ma'i Manawa | Iulai 2003 | Māhele 2 |
| NCT01798225 | Ke Kulanui Lapaʻau o South Carolina|National Center for Research Resources (NCRR) | ʻO ka maʻi maʻi periodontal|Maʻi maʻi maʻi ʻano 2 | Kekemapa 2007 | Māhele 4 |
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| NCT00388778 | Shahid Beheshti University of Medical Sciences | ʻAneʻe| | ʻOkakopa 2005 | Māhele 2|Mahele 3 |
| NCT01087476 | Ke Kulanui Autonomous Metropolitan|Instituto Nacional de Cancerologia de Mexico | Mucositis | Mei 2010 | Māhele 2 |
| NCT02174757 | ʻO CD Pharma India Pvt.Ltd.|Sree Mookambika Institute of Dental Sciences | Periodontitis mau | ʻAukake 2014 | Māhele 3 |
| NCT03911440 | Halema'i Kula Nui o Taiwan | Pneumonia atypical | Nowemapa 10, 2018 | Pili 'ole |
| NCT02553083 | Kikowaena Laau o Rabin | ʻO ka maʻi bacteria ma muli o ka Helicobacter Pylori (H. Pylori) | ʻOkakopa 22, 2015 | Māhele 4 |
| NCT04234945 | ʻO ka Hale Hōʻikeʻike Kula ʻo Ahmadu Bello | ʻAi ʻole, Wahine|Pelvic Inflammatory Disease | Ianuali 13, 2020 | Pili 'ole |
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| NCT04153604 | Pūnaehana Ola Methodist | Cirrhosis|Peritonitis Bacterial Spontaneous | Nowemapa 4, 2019 |
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| NCT03116659 | ʻO James J. Peters Hale Hōʻikeʻike Hoʻonaʻauao Veterans Affairs | ʻO Lymphoma, T-Cell, Cutaneous | Pepeluali 1, 2018 | Māhele mua 1 |
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| NCT01198912 | Halemai Kulanui, Ghent | ʻO Rhinosinusitis mau|polip ihu | Nowemapa 22, 2011 | Māhele 2 |
| NCT02016365 | Kulanui ʻo Umeå | ʻO Transthyretin Amyloidosis|Cardiomyopathy | Pepeluali 2012 | Māhele 2 |
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| NCT01323101 | Kulanui o Kaleponi Hema | Cystic Fibrosis | ʻApelila 2008 | Māhele 4 |
| NCT00829764 | ʻO Teva Pharmaceuticals USA | Ola ola | ʻOkakopa 2006 | Māhele 1 |
| NCT01668498 | AIO-Studien-gGmbH | Ras-wildtype Colorectal Cancer | Mei 2011 | Māhele 2 |
| NCT01030666 | Peter Eickholz|Heidelberg University|Dr.ʻAukake Wolff GmbH & Co. KG Arzneimittel|Gaba International AG|Goethe University | Periodontitis | ʻApelila 2007 | Māhele 4 |
| NCT00012688 | Keʻena ʻOihana ʻAmelika Hui Pū ʻIa|Colgate-Periogard-Dentsply|Keʻena o ka noiʻi a me ka hoʻomohala ʻana o VA | ʻO ka maʻi maʻi maʻi ʻaʻai|Pono Glycemic Control|Ka maʻi maʻi āpau | Pili 'ole | |
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| NCT02328469 | Ke Kula Nui Lapaʻau Ljubljana|Keʻena noiʻi Slovenia|Ke Kula Lapaʻau o ke Kulanui o Ljubljana, Slovenia|Ke Kulanui ʻo Harvard | Aseptic Meningitis | Iune 2014 |
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| NCT02606032 | Hamilton Health Sciences Corporation|Hamilton Academic Health Sciences Organization | Ulcerative Colitis | Mei 2016 | Māhele 2 |
| NCT01465802 | Pfizer | ʻO ka maʻi maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi ʻole (NSCLC) | Kekemapa 26, 2011 | Māhele 2 |
| NCT02623959 | MD Anderson Cancer Center | Ka ma'i ma'i ma'i |Malignant Pleural Effusions | ʻApelila 27, 2016 | Māhele 4 |
| NCT03481972 | IRCCS Policlinico S. Matteo | TTR Cardiac Amyloidosis | ʻApelila 11, 2018 | Māhele 3 |
| NCT00428818 | Ke Kulanui o Texas Southwestern Medical Center | Ka ma'i ma'i | ʻAukake 2005 | Pili 'ole |
| NCT01935622 | Ke Kulanui o Commonwealth Virginia | ʻAʻole-ischemic Cardiomyopathy|Systolic Heart Failure (NYHA II-III) | Iulai 2012 | Māhele 2 |
| NCT01886560 | Ke Kulanui o Sun Yat-sen | Puhi Maka | Kepakemapa 2013 | Māhele 2|Mahele 3 |
| NCT04239755 | Ke Kulanui ʻo Damanhour|Ke Kulanui ʻo Tanta | ʻEha Loko Traumatic | Kekemapa 15, 2019 | Māhele 4 |
| NCT02204254 | Center Hospitalier Universitaire de Nice | ʻO Rosacea | Malaki 2014 | Pili 'ole |
| NCT00837213 | Stiefel, he Hui GSK|GlaxoSmithKline | ʻAneʻe | ʻAukake 2007 | Māhele 4 |
| NCT03115177 | Kikowaena Lapaau o ke Kulanui o Rush | Osteoarthritis | Nowemapa 2015 | Pili 'ole |
| NCT03618108 | ʻO Cadrock Pty. Ltd.|Ke kikowaena no nā maʻi maʻi ʻai, Australia | ʻO ka maʻi ʻehaʻeha|Chlamydophila Pneumoniae Infections | ʻApelila 4, 2018 | Māhele 2 |
| NCT03435952 | MD Anderson Cancer Center|BioMed Valley Discoveries, Inc|Merck Sharp & Dohme Corp. | ʻO ka Neoplasm ʻino o ka umauma|Nā Neoplasma ʻino o nā ʻōpū ʻōpū|Nā neoplasma ʻino o ka lolo o ka maka a me nā ʻāpana ʻē aʻe o ka Pūnaehana Nervous Central|Nā Neoplasms ʻino o nā ʻōpū wahine|Nā Neoplasms ʻino o ka lua i wehewehe ʻole ʻia a me nā wahi i ʻike ʻole ʻia | Nā Neoplasms ʻino o ke kino kūʻokoʻa. Nā Paena|Nā Neoplasma ʻino o ka Lehelehe waha a me ka Pharynx|Nā Neoplasma ʻino o nā ʻōpū o ke kāne kāne|Nā neoplasma ʻino o ka Mesothelial a me ka ʻiʻo palupalu|Nā neoplasma ʻino o ka hanu a me ka Intrathoracic Organs|Nā Neoplasma ʻino o ka Thyroid a me nā Neoplasms Endocrine ʻē aʻe | Iulai 10, 2018 | Māhele 1 |
| NCT01867294 | Academic and Community Cancer Research United|National Cancer Institute (NCI) | ʻO Neoplasm Malignant Kiʻekiʻe|Dermatologic Complication | ʻAukake 31, 2012 | Māhele 2 |
| NCT01677286 | Ke Kulanui o Boston | Amyloidosis | Iulai 2012 | Māhele 2 |
| NCT00511875 | ʻO Thomas Gardner|Punahana ʻImi ʻImi ʻImi ʻōpio|Milton S. Hershey Medical Center | ʻO ka maʻi maʻi Retinopathy | Iulai 2008 | Māhele 2 |
| NCT04108897 | Ke Kulanui o Johns Hopkins | ʻO Rosacea | Kepakemapa 17, 2019 | Māhele mua 1 |
| NCT00631501 | Kaunas University of Medicine|University Hospital, Linkoeping | Lateral Epicondylalgia (Kuʻekuʻe Tennis) | Pili 'ole | |
| NCT02203682 | Ke Kulanui o Sun Yat-sen | Graves Ophthalmopathy|Ma'i Kupapau|Ma'i Maka|Ma'i Thyroid|Ma'i ma'i Endocrine System|Ma'i Maka, Hooilina|Hyperthyroidism|Ma'i Autoimmune|Ma'i Kapilikia. | Iulai 2014 | Māhele 2 |
| NCT02005653 | 'Aha 'Ailika no ka 'Imi Lapa'au | Filarial;Hoʻopiʻi | Pepeluali 2009 | Māhele 4 |
| NCT03585140 | Centro Dermatológico Kauka Ladislao de la Pascua | Acne Vulgaris|Hoʻololi Meaʻai | Ianuali 1, 2016 | Pili 'ole |
| NCT02147262 | Ke Kula Nui Lapaʻau Ljubljana|Ke Kulanui o Ljubljana Kula Lapaʻau, Slovenia|Ke Kulanui Lapaʻau o Vienna|Ke Kulanui ʻo Harvard | Atrophic Acrodermatitis mau | Iulai 2013 | Pili 'ole |
| NCT02220751 | Ke Kulanui o Sao Paulo|Fundação de Amparo a Pesquisa do Estado de São Paulo | Periodontitis|Ke ʻano maʻi diabetes 2 | Malaki 2009 | Māhele 3 |
| NCT01825408 | Ke Kulanui o North Carolina, Chapel Hill | Sinusitis | Pepeluali 2013 | Māhele 4 |
| NCT02884713 | ʻO ka Halemai Kūikawā a me ke Keena Noiʻi ʻo King Faisal | KA MAU MAU | Iune 2013 | Pili 'ole |
| NCT02726646 | Ke Kulanui o Campinas, Palakila|Pontificia Universidade Catolica de Sao Paulo | Periodontitis mau | Iune 2015 | Māhele 2 |
| NCT00883818 | Keena Lapaʻau Samsung | ʻO ka ʻōpū o ka ʻōpū | Ianuali 2007 | Māhele 4 |
| NCT00829790 | ʻO Teva Pharmaceuticals USA | Ola ola | ʻOkakopa 2006 | Māhele 1 |
| NCT01949233 | Ke Kulanui o Oxford|Oxford University Hospitals NHS Trust | ʻO Marfan Syndrome | ʻOkakopa 2013 | Māhele 2 |
| NCT01518192 | Ke Kula Nui Lapaʻau Ljubljana|Slovenian Research Agency | Erythema Migrans|Ma'i ma'i Post-Lyme | Iune 2006 | Māhele 4 |
| NCT02845024 | Ke Kulanui ʻo Islam Azad, Tehran | ʻO ka maʻi diabetes Mellitus me ka maʻi periodontal | Kepakemapa 2014 | Pili 'ole |
| NCT01879930 | Halema'i Kula Nui ma Berne | ʻEha Pelvic Pain Syndrome|Maʻi ʻeha o ka ʻōpū | Nowemapa 2012 | Māhele 4 |
| NCT00041977 | ʻO CollaGenex Pharmaceuticals | Acne Rosacea | Iune 2002 | Māhele 3 |
| NCT02341209 | Halemai Nui o Rochester | ʻO Lymphoma T-cell Cutaneous|Mycosis Fungoides|Sezary Syndrome | Pepeluali 6, 2018 | Māhele 2 |
| NCT00002872 | Hikina Cooperative Oncology Group|National Cancer Institute (NCI)|North Central Cancer Treatment Group | Ka maʻi maʻi maʻi metastatic | Nowemapa 1996 | Māhele 3 |
| NCT03162497 | Ke Kulanui Lapaʻau o Vienna | ʻO nā maʻi maʻi maloʻo|Maibomian Gland Dysfunction | Ianuali 8, 2018 | Māhele 4 |
| NCT01418742 | Gesellschaft fur Medizinische Innovation ?Hamatologie a me Onkologie mbH|ClinAssess GmbH | Ka ma'i ma'i 'a'ai | ʻAukake 2011 | Māhele 2 |
| NCT00980148 | National Institute of Allergy and Infectious Diseases (NIAID) | Ka ma'i Chlamydial | Kekemapa 2009 | Māhele 3 |
| NCT03342456 | ʻO ke kolu o ka Halemai Xiangya o Central South University|Livzon Pharmaceutical Group Inc.|Yung Shin Pharm.Ind. Co., Ltd. | Duodenal Ulcer Ma muli o Helicobacter Pylori | Kekemapa 13, 2017 | Māhele 4 |
| NCT04310930 | Ke Kulanui o Queensland|Keʻena Ola Aupuni o Australia|Puna Haukapila o nā keiki|Cystic Fibrosis Foundation|Ke Kulanui o Newcastle|Ke Kulanui ʻo Griffith|Ke Keʻena Lapaʻau ʻo Erasmus|Ke Kulanui ʻo Monash|Ke Kulanui o Copenhagen|Hôpital Cochin|South Australian Health and Medical Research Institute|University o Melbourne|Ke Kulanui ʻo James Cook, Queensland, Australia|Murdoch Childrens Research Institute | ʻO ka maʻi ʻeha ma muli o ka Mycobacteria (Diagnosis) | Malaki 2020 | Māhele 2|Mahele 3 |
| NCT03709459 | Kirby Institute|South Australian Health and Medical Research Institute|Monash University | Kāohi STI | Kekemapa 17, 2019 |
|
| NCT04067011 | Emergent BioSolutions|Biomedical Advanced Research and Development Authority | Anthrax | ʻAukake 12, 2019 | Māhele 2 |
| NCT02844634 | ʻO ka Hale Hōʻikeʻike o British Columbia no ka mālama ʻana i ka maʻi | HIV|Syphilis | Mei 15, 2018 | Māhele 4 |
| NCT00647959 | Mylan Pharmaceuticals | Ola ola | Malaki 2006 | Māhele 1 |
| NCT00170222 | Hale Kauka Alkmaar | ʻO ka maʻi ʻāʻī ʻāʻī | Iulai 2002 | Māhele 4 |
| NCT03075891 | Galderma | ʻO Rosacea | Iulai 5, 2017 | Māhele 4 |
| NCT00031499 | National Institute of Allergy and Infectious Diseases (NIAID) | ʻO Syphilis | Iune 2000 | Māhele 3 |
| NCT01205464 | Ke Kulanui ʻo Linkoeping | ʻO ka luhi|Ka ʻeha Radicular|Paresis|Paresis | Pepeluali 2005 | Pili 'ole |
| NCT01301586 | Nexgen Dermatologic, Inc. | ANE VULGARIS | Nowemapa 2010 | Māhele 1|Mahele 2 |
| NCT02305940 | Ke Kulanui Imperial Lādana | ʻO ka maʻi ʻāʻī ʻāʻī o ka manawa (COPD) | Iulai 2014 | Māhele 3 |
| NCT00351182 | Dong-Min Kim|Hakapila Kulanui o Chosun | Holoi Typhus | Kepakemapa 2005 | Māhele 3 |
| NCT03334682 | Halema'i Kula Nui o Nantes | ʻAneʻe vulgaris | Ianuali 31, 2018 | Māhele 3 |
| NCT01788215 | Kulanui o Rochester | ʻO ka Polycystic Ovarian Syndrome (PCOS)|Kaʻi ʻana o ka maʻi maʻamau|Ka nui o Androgen | Nowemapa 2010 | Māhele 3 |
| NCT03076281 | ʻO Sidney Kimmel Cancer Center ma ke Kulanui ʻo Thomas Jefferson|Ke Kulanui ʻo Thomas Jefferson | Larynx|LEP|Waha waha|Pharynx | ʻApelila 3, 2017 | Māhele 2 |
| NCT00439166 | Hamilton Health Sciences Corporation|The Physicians' Services Incorporated Foundation|Ke Kulanui o McMaster | ʻO ka maʻi o Alzheimer | Pepeluali 2007 | Māhele 3 |
| NCT02463942 | Ke Kula Nui Lapaʻau Ljubljana|Ke Kula Lapaʻau o Ljubljana, Slovenia | ʻO Encephalitis maʻi maʻi | Kepakemapa 2014 | Pili 'ole |
| NCT00803842 | Kulanui ʻĀkau komohana | ʻO ka maʻi maʻi maʻi ʻaʻole liʻiliʻi | ʻOkakopa 2008 | Pili 'ole |
| NCT02086591 | Kulanui o Rochester | ʻO ka maʻi maʻi B-Cell Lymphoma Nui|Lymphoma Cell Mantle Recurrent|Lymphoma, Follicular|Marginal Zone B-Cell Lymphoma|Malignant Lymphoma - Lymphoplasmacytic|Waldenstrom Macroglobulinemia|Liʻi Lymphocytic Lymphoma|Chronic Lymphocytic Lymphoma (CLL) Leukemia (CLL) | Malaki 2014 | Māhele 2 |
| NCT03980223 | Ke Kulanui o Kaleponi, Kapalakiko|University of Washington|National Institute of Allergy and Infectious Diseases (NIAID)|Mayne Pharma International Pty Ltd|Ke Keʻena Ola Aupuni o Kapalakiko. | Gonorrhea|Chlamydia|Syphilis | Nowemapa 26, 2019 | Māhele 4 |
| NCT00355459 | Ke Kulanui o Texas Southwestern Medical Center | Ma'i Maka maloo | ʻAukake 2005 | Pili 'ole |
| NCT01254799 | Omar Mamdouh Shaaban|Assiut University | ʻO ka ʻōpū koko | Ianuali 2008 | Māhele 3 |
| NCT01547325 | NanoSHIFT LLC|Keʻena Palekana o ʻAmelika Hui Pū ʻIa | Nā ʻEha Hoʻopaʻa ʻia | Mei 2012 | Pili 'ole |
| NCT00653380 | Par Pharmaceutical, Inc.|Anapharm | No ka hoʻoholo ʻana i ka bioequivalence ma lalo o nā kūlana hoʻokē ʻai | Kepakemapa 1999 | Māhele 1 |
| NCT00635609 | Warner Chilcott | ʻAneʻe vulgaris | Malaki 2008 | Māhele 4 |
| NCT03765931 | Institut de Recherche pour le Development | ʻO ke kuni | Iulai 2016 | Māhele 4 |
| NCT01160640 | Harold Wiesenfeld|Ke Kula Nui o Pittsburgh | ʻO ka maʻi ʻaʻa ʻāʻī | Nowemapa 2010 | Māhele 2 |
| NCT01756833 | Ke Kulanui o Maryland, Baltimore|National Institute on Aging (NIA) | Aneurysm | Mei 2013 | Māhele 2 |
| NCT00688064 | Galderma | Ko'iko'i Acne Vulgaris | ʻAukake 2008 | Māhele 3 |
| NCT01320033 | Galderma | ʻAneʻe vulgaris | Malaki 29, 2011 | Māhele 2 |
| NCT03397004 | St. Michael's Hospital, Toronto|Barrow Neurological Institute|Duke University|Feinstein Institute for Medical Research|University of Pittsburgh|Sunnybrook Health Sciences Center | Hoʻoilina Hemorrhagic Telangiectasia (HHT) | Kepakemapa 12, 2018 | Māhele 2 |
| NCT01635530 | Halemai Kula Nui o Turku | ʻO Lyme Neuroborreliosis | ʻAukake 2012 | Māhele 4 |
| NCT03727620 | Ke Kulanui ʻo Mohammed V Souissi | ʻO ka maʻi maʻi maʻi | Ianuali 6, 2014 | Māhele 1|Mahele 2 |
| NCT02688738 | Rothman Institute Orthopedic | Propionibacterium | Malaki 2015 | Pili 'ole |
| NCT00358462 | Ke Kulanui o Wakinekona|National Institute of Allergy and Infectious Diseases (NIAID) | Urethritis | Ianuali 2007 | Māhele 3 |
| NCT02864550 | ʻO ka Hale Hōʻikeʻike o British Columbia no ka mālama ʻana i ka maʻi | Syphilis|Ma'i ma'i ho'ouna 'ia ma ke kino | ʻAukake 15, 2019 | Māhele 4 |
| NCT01595594 | Ke Kulanui o Sao Paulo|Fundação de Amparo a Pesquisa do Estado de São Paulo | ʻO ka maʻi maʻi maʻi|ʻano maʻi diabetes 2 | Malaki 2010 | Māhele 3 |
| NCT00964834 | PharmAthene, Inc.|National Institute of Health (NIH)|Medarex|Quintiles, Inc.|Keʻena o ke Ola a me nā lawelawe kanaka | Anthrax | Iulai 2009 | Māhele 1 |
| NCT01809444 | Ke Kulanui o Sun Yat-sen | Nā Ophthalmopathies pili i kouroid | Nowemapa 2012 | Māhele 2|Mahele 3 |
| NCT01590082 | MD Anderson Cancer Center|National Institute of Health (NIH)|National Cancer Institute (NCI) | Melanoma | Nowemapa 2012 | Māhele 1|Mahele 2 |
| NCT00207584 | Nā kikowaena no ka hoʻopaʻa ʻana a me ka pale ʻana i ka maʻi | Mycoplasma Pneumoniae | Ianuali 1994 | Pili 'ole |
| NCT00775177 | ʻO Ranbaxy Laboratories Limited|Ranbaxy Inc. | Ola ola | Iune 2005 | Pili 'ole |
| NCT03462329 | Ke Kulanui Lapaʻau Ljubljana | Erythema Migrans | Iune 1, 2018 | Pili 'ole |
| NCT00000403 | Ke Kulanui o Indiana|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institute on Aging (NIA) | Osteoarthritis | Kepakemapa 1996 | Māhele 3 |
| NCT03508232 | Ke Kulanui o Alberta|Hakapila Royal Alexandra | ST Segment Elevation Myocardial Infarction|Haʻule Puʻuwai | Ianuali 6, 2020 | Māhele 2 |
| NCT02553473 | Halemai Sorlandet HF | Neuroborreliosis, Borrelia Burgdorferi | ʻOkakopa 2015 | Māhele 3 |
| NCT02207556 | Ke Kulanui Lapaʻau o Wisconsin | ʻO ka Amyloidosis Systemic | ʻOkakopa 1, 2014 | Māhele 2 |
| NCT01783106 | ʻO ka Halemai Kula Nui ʻo Royal Liverpool|National Association for Colitis and Crohn's Disease|National Institute for Health Research, United Kingdom | ʻO ka maʻi o Crohn | Pepeluali 1, 2014 | Māhele 2 |
| NCT00353743 | Halemai de Clinicas de Porto Alegre | Hoʻopaʻa keiki, Septic | Mei 2006 | Pili 'ole |
| NCT01727973 | Ke Kulanui o Sun Yat-sen | Graves Ophthalmopathy|Ma'i Kupapau|Ma'i Maka|Ma'i Thyroid|Ma'i ma'i Endocrine System|Ma'i Maka, Hooilina|Hyperthyroidism|Ma'i Autoimmune|Ma'i Kapilikia. | ʻOkakopa 2012 | Māhele 1|Mahele 2 |
| NCT00857038 | Lapaʻau Lapaʻau Alkmaar|Leiden University Medical Center|University of Amsterdam | ʻO ka maʻi maʻi ʻāʻī ʻāʻī|Pulmonary Emphysema | ʻApelila 2009 | Māhele 4 |
| NCT02774993 | Halemai Kula Nui o Lahui, Singapore|Hakapila o Tan Tock Seng|Ke Kula Nui, Singapore|A*Star | Ka maʻi maʻi maʻi | Kepakemapa 2015 | Māhele 2 |
| NCT03474458 | IRCCS Policlinico S. Matteo | ʻO ka maʻi AL Amyloidosis | Pepeluali 11, 2019 | Māhele 2|Mahele 3 |
| NCT02874430 | ʻO Sidney Kimmel Cancer Center ma ke Kulanui ʻo Thomas Jefferson|Ke Kulanui ʻo Thomas Jefferson | Ka ma'i ma'i o ka umauma|Adenocarcinoma ma'ema'e o ka ma'i endometrial|Adenocarcinoma serous endometrial|Ma'i ma'i ma'i o ka Uterine | Iune 8, 2016 | Māhele 2 |
| NCT00016835 | Ke Kulanui o Michigan|National Institute of Dental and Craniofacial Research (NIDCR) | ʻO ka maʻi periodontal|Diabetes Mellitus, Type 2 | ʻOkakopa 17, 2001 | Māhele 2 |
| NCT00064766 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Ke koko Endometrial|Ma'i Manawa | Pepeluali 2003 | Māhele 4 |
| NCT00803452 | Kulanui o Louisville | Blepharitis | Iulai 2008 | Māhele 4 |
| NCT01434173 | Bayer|RTI Health Solutions | ʻEha ʻĀpaʻa i hoʻohana ʻia i ka lāʻau | Iulai 2001 |
|
| NCT00126204 | Halema'i Barnes-Jewish | Aortic Aneurysm | Malaki 2004 | Pili 'ole |
| NCT01917721 | Ola Hawaii Pakipika | ʻO ka maʻi ʻo Kawasaki|Coronary Aneurysm | ʻOkakopa 2013 | Māhele 2 |
| NCT02775695 | Ke Kulanui Lapaʻau o Wisconsin | ʻO ka maʻi maʻi pancreatic hiki ke hoʻihoʻi ʻia | ʻApelila 3, 2017 | Māhele 2 |
| NCT03824340 | Halemai Aljazeera | ʻAʻole hānau keiki | Ianuali 30, 2019 | Pili 'ole |
| NCT01847976 | Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation | ʻeha | ʻAukake 2013 | Māhele 2 |
| NCT02850913 | Ke Kulanui o Makerere|Ke Kulanui o Oxford | Hoʻopaʻa ʻia | Kepakemapa 5, 2016 | Māhele 2 |
| NCT00764361 | NanoSHIFT LLC | Ka ma'i ma'i ma'i wāwae wāwae | Ianuali 2009 | Māhele 2 |
| NCT02036528 | ʻO Royer Biomedical, Inc. | Ka ma'i ma'i ma'i wawae wawae diabetic | Ianuali 2014 | Māhele 1|Mahele 2 |
| NCT01661985 | ʻAha Kalana ʻo Ostergotland, Suedena|Statens Serum Institut | Urethritis|Cervicitis|Ma'i Mycoplasma Genital|Chlamydia Trachomatis | Pepeluali 2010 | Māhele 4 |
| NCT01380483 | Par Pharmaceutical, Inc.|Anapharm | No ka hoʻoholo ʻana i ka bioequivalence ma lalo o nā kūlana hoʻokē ʻai | Ianuali 2000 | Māhele 1 |
| NCT00648180 | Mylan Pharmaceuticals | Ola ola | Iulai 2005 | Māhele 1 |
| NCT01426269 | Galderma Laboratories, LP | ʻO Rosacea | Kepakemapa 2011 | Māhele 4 |
| NCT02753426 | Ke Kulanui o Kaleponi, Kapalakiko | ʻO ka maʻi maʻi maʻi ʻaʻai|Ka maʻi maʻi cardiovascular | ʻApelila 2016 | Māhele 1 |
| NCT02583282 | Postgraduate Institute of Medical Education and Research | ʻO ka hoʻoheheʻe ʻia ʻana o ka pleural malignant | ʻAukake 1, 2015 | Pili 'ole |
| NCT02927496 | ʻO ka Task Force for Global Health|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Iune 19, 2018 | Māhele 3 |
| NCT00652795 | Par Pharmaceutical, Inc.|Anapharm | No ka hoʻoholo ʻana i ka bioequivalence ma lalo o nā kūlana hoʻokē ʻai | Iulai 2004 | Māhele 1 |
| NCT03956212 | Ke Kula Nui Lapaʻau Ljubljana|Ke Kula Lapaʻau o Ljubljana, Slovenia | Erythema Migrans | Iune 1, 2017 | Pili 'ole |
| NCT00855595 | Bayer | Papulopustular Rosacea | Pepeluali 2009 | Māhele 4 |
| NCT03457636 | Derm Research, PLLC | ʻAneʻe | Malaki 19, 2018 | Māhele 4 |
| NCT02894268 | Sir Run Run Shaw Hospital | ʻO ka maʻi Helicobacter Pylori | Pepeluali 2016 | Māhele 4 |
| NCT03465774 | MD Anderson Cancer Center|National Cancer Institute (NCI) | ʻO ka hoʻoheheʻe ʻia ʻana o ka pleural malignant | Malaki 8, 2018 | Māhele mua 1 |
ʻO ke kinona
Manaʻo18Nā papahana Loiloi Kūlike Kūlike i ʻae ʻia4, a6nā papahana ma lalo o ka ʻae ʻia.
Ua hoʻokumu ka ʻōnaehana hoʻokele maikaʻi honua kiʻekiʻe i ke kumu kūʻai.
Holo ka nānā ʻana i ka maikaʻi ma ke ola holoʻokoʻa o ka huahana e hōʻoia i ka maikaʻi a me ka hopena therapeutic.
Kākoʻo ka hui ʻoihana Regulatory Affairs i nā koi maikaʻi i ka wā o ke noi a me ke kau inoa ʻana.
Kolea Countec Bottled Packaging Line
ʻO Taiwan CVC Bottled Packaging Line
ʻO Italia CAM Board Packaging Line
Mekini Fette Compacting German
ʻO Iapana Viswill Tablet ʻIke
Keena Mana DCS
Ka launa pū ʻana o ka honua
ʻO ka launa pū ʻana o ka hale
E kākau i kāu leka ma aneʻi a hoʻouna mai iā mākou
