ʻO Doxycycline Hyclate
Kāpae
ʻO ka Doxycycline hyclate kahi lāʻau lapaʻau [1].
ʻO ka Doxycycline hyclate kahi hua o ka tetracycline a loaʻa iā ia nā hana anti-inflammatory a me antimicrobial. Kāohi ʻo Doxycycline i ka hoʻopiʻi hou ʻana o ka maʻi dengue i loko o ka vitro me kahi ʻano hilinaʻi wela. ʻO ka waiwai IC50 he 52.3μM ma 37°C a me 26.7μM ma 40°C. Kāohi ia i ka maʻi dengue ma o ke kāohi ʻana i ka protease serine NS2B-NS3 o ka maʻi. 60μM doxycycline ho'ēmi i ka CPE o ka DNEV2-infected cell [1].
Ua ʻike ʻia ʻo Doxycycline he mea hoʻokae o MMP. Hoʻemi ka lāʻau Doxycycline i nā pae MMP-8 a me -9 a keʻakeʻa i ka hōʻike ʻana o ka kiko MMP-2 a me MMP-9. Eia kekahi, ʻo ka mālama ʻana me ka doxycycline e hoʻemi nui i ka ulu ʻana o nā aneurysms intracranial. Ua hōʻike pū ʻia ʻo Doxycycline he lāʻau anti-inflammatory ma muli o kāna kaohi ʻana i nā metalloproteinases matrix. Eia kekahi, loaʻa i ka doxycycline ka hana antimalarial potent me ka waiwai IC50 o 320nM ma 96h in vitro [2, 3].
Kuhikuhi:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. ʻO ka hopena inhibitory o doxycycline e kūʻē i ka hoʻopiʻi ʻana i ka maʻi dengue i loko o ka vitro. Arch Virol. 2014 Apr;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Ke kuleana o ka matrix metalloproteinases (MMPs) a me ka MMP inhibitors ma intracranial aneurysms: he ʻatikala loiloi. Med J Islam Repub Iran. 2013 Nov;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. In vitro a in vivo antimalarial efficacies o optimized tetracyclines. Nā ʻĀpana Antimicrob Chemother. 2013 Iulai;57(7):3131-6.
wehewehe
ʻO ka Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), he lāʻau'alopelo, he mea hoʻoikaika waha a me ka laulā ākea metalloproteinase (MMP) inhibitor [1].
Hoao Hoao
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NCT00428818 | Ke Kulanui o Texas Southwestern Medical Center | Ka ma'i ma'i | ʻAukake 2005 | Pili ʻole |
NCT01935622 | Ke Kulanui ʻO Virginia Commonwealth | ʻAʻole-ischemic Cardiomyopathy|Systolic Heart Failure (NYHA II-III) | Iulai 2012 | Māhele 2 |
NCT01886560 | Ke Kulanui o Sun Yat-sen | Puhi Maka | Kepakemapa 2013 | Māhele 2|Mahele 3 |
NCT04239755 | Ke Kulanui ʻo Damanhour|Ke Kulanui ʻo Tanta | ʻEha Loko Traumatic | Kekemapa 15, 2019 | Māhele 4 |
NCT02204254 | Center Hospitalier Universitaire de Nice | ʻO Rosacea | Malaki 2014 | Pili ʻole |
NCT00837213 | Stiefel, he Hui GSK|GlaxoSmithKline | ʻAneʻe | ʻAukake 2007 | Māhele 4 |
NCT03115177 | Kikowaena Lapaau o ke Kulanui o Rush | Osteoarthritis | Nowemapa 2015 | Pili ʻole |
NCT03618108 | ʻO Cadrock Pty. Ltd.|Ke kikowaena no nā maʻi digestive, Australia | ʻO ka maʻi ʻehaʻeha|Chlamydophila Pneumoniae Infections | ʻApelila 4, 2018 | Māhele 2 |
NCT03435952 | MD Anderson Cancer Center|BioMed Valley Discoveries, Inc|Merck Sharp & Dohme Corp. | ʻO ka Neoplasm ʻino o ka umauma|Nā Neoplasma ʻino o nā ʻano hoʻoheheʻe ʻana|Nā neoplasma ʻino o ka lolo o ka maka a me nā ʻāpana ʻē aʻe o ka Pūnaehana Nervous Central|Nā Neoplasma ʻino o nā ʻōpū o ka wahine|Nā Neoplasms ʻino o ka lua i wehewehe ʻole ʻia a me nā wahi ʻaʻole i hōʻike ʻia Paena|Na Neoplasms ino o Lehelehe Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Mesothelial and Soft Tissue|Malignant Neoplasms of Respiratory and Intrathoracic Organs|Malignant Neoplasms of Thyroid and Other Endocrine Glands|Malignant Neoplasms of Urinary Tract | Iulai 10, 2018 | Māhele 1 |
NCT01867294 | Academic and Community Cancer Research United|National Cancer Institute (NCI) | ʻO Neoplasm Malignant Kiʻekiʻe|Dermatologic Complication | ʻAukake 31, 2012 | Māhele 2 |
NCT01677286 | Ke Kulanui o Boston | Amyloidosis | Iulai 2012 | Māhele 2 |
NCT00511875 | ʻO Thomas Gardner|Punahana ʻImi ʻImi ʻImi ʻōpio|Milton S. Hershey Medical Center | ʻO Retinopathy Diabetic | Iulai 2008 | Māhele 2 |
NCT04108897 | Ke Kulanui o Johns Hopkins | ʻO Rosacea | Sepatemaba 17, 2019 | Māhele mua 1 |
NCT00631501 | Kaunas University of Medicine|University Hospital, Linkoeping | Epicondylalgia Lateral (Kuʻekuʻe Tennis) | Pili ʻole | |
NCT02203682 | Ke Kulanui o Sun Yat-sen | Graves Ophthalmopathy|Ma'i Kupapau|Ma'i Maka|Ma'i Thyroid|Ma'i ma'i Endocrine System|Ma'i Maka, Ho'oilina|Hyperthyroidism|Ma'i Autoimmune|Ma'i Ka'i | Iulai 2014 | Māhele 2 |
NCT02005653 | 'Aha 'Ailika o ka 'Imi Lapa'au | Filarial; Hoʻopiʻi | Pepeluali 2009 | Māhele 4 |
NCT03585140 | Centro Dermatológico Kauka Ladislao de la Pascua | Acne Vulgaris|Hoʻololi Meaʻai | Ianuali 1, 2016 | Pili ʻole |
NCT02147262 | Ke Kula Nui Lapaʻau Ljubljana|Ke Kulanui o Ljubljana Kula Lapaʻau, Slovenia|Ke Kulanui Lapaʻau o Vienna|Ke Kulanui ʻo Harvard | Atrophic Acrodermatitis mau | Iulai 2013 | Pili ʻole |
NCT02220751 | Ke Kulanui o Sao Paulo|Fundação de Amparo a Pesquisa do Estado de São Paulo | Periodontitis|Maʻi maʻi maʻi type 2 | Malaki 2009 | Māhele 3 |
NCT01825408 | Ke Kulanui o North Carolina, Chapel Hill | Sinusitis | Pepeluali 2013 | Māhele 4 |
NCT02884713 | ʻO ka Halemai Kūikawā a me ke Keena Noiʻi ʻo King Faisal | KA MAU MAU | Iune 2013 | Pili ʻole |
NCT02726646 | Ke Kulanui o Campinas, Palakila|Pontificia Universidade Catolica de Sao Paulo | ʻO ka maʻi maʻi maʻi | Iune 2015 | Māhele 2 |
NCT00883818 | Kikowaena Lapaau Samsung | ʻO ka ʻōpū ʻeha | Ianuali 2007 | Māhele 4 |
NCT00829790 | ʻO Teva Pharmaceuticals USA | Ola ola | ʻOkakopa 2006 | Māhele 1 |
NCT01949233 | Ke Kulanui o Oxford|Oxford University Hospitals NHS Trust | ʻO Marfan Syndrome | ʻOkakopa 2013 | Māhele 2 |
NCT01518192 | Ke Kula Nui Lapaʻau Ljubljana|Slovenian Research Agency | Erythema Migrans|Ma'i ma'i Post-Lyme | Iune 2006 | Māhele 4 |
NCT02845024 | Ke Kulanui ʻo Islamic Azad, Tehran | ʻO ka maʻi diabetes Mellitus me ka maʻi periodontal | Kepakemapa 2014 | Pili ʻole |
NCT01879930 | ʻO ka Halemai Kula Nui ʻo Inselspital, Berne | Ma'i 'Eha Pelvic Mau'u|Ma'i 'eha o ka Puhi | Nowemapa 2012 | Māhele 4 |
NCT00041977 | ʻO CollaGenex Pharmaceuticals | Acne Rosacea | Iune 2002 | Māhele 3 |
NCT02341209 | Halemai Nui o Rochester | ʻO Lymphoma T-cell Cutaneous|Mycosis Fungoides|Sezary Syndrome | Pepeluali 6, 2018 | Māhele 2 |
NCT00002872 | Hikina Cooperative Oncology Group|National Cancer Institute (NCI)|North Central Cancer Treatment Group | Ka maʻi maʻi maʻi maʻi | Nowemapa 1996 | Māhele 3 |
NCT03162497 | Ke Kulanui Lapaʻau o Vienna | ʻO nā maʻi maʻi maka maloʻo|Pele ʻo Meibomian Gland | Ianuali 8, 2018 | Māhele 4 |
NCT01418742 | Gesellschaft fur Medizinische Innovation ? Hamatologie a me Onkologie mbH|ClinAssess GmbH | Ka maʻi maʻi ʻaʻai | ʻAukake 2011 | Māhele 2 |
NCT00980148 | National Institute of Allergy and Infectious Diseases (NIAID) | Ka ma'i Chlamydial | Kekemapa 2009 | Māhele 3 |
NCT03342456 | ʻO ke kolu o ka Halemai Xiangya o Central South University|Livzon Pharmaceutical Group Inc.|Yung Shin Pharm. Ind. Co., Ltd. | Duodenal Ulcer Ma muli o Helicobacter Pylori | Kekemapa 13, 2017 | Māhele 4 |
NCT04310930 | Ke Kulanui o Queensland|Australian Government Department of Health|Children's Hospital Foundation|Cystic Fibrosis Foundation|Newcastle University|Griffith University|Erasmus Medical Center|Monash University|University of Copenhagen|Hôpital Cochin|South Australian Health and Medical Research Institute|University o Melbourne|Ke Kulanui ʻo James Cook, Queensland, Australia|Murdoch Childrens Research Institute | ʻO ka maʻi ʻeha ma muli o ka Mycobacteria (Diagnosis) | Malaki 2020 | Māhele 2|Mahele 3 |
NCT03709459 | Kirby Institute|South Australian Health and Medical Research Institute|Monash University | Kāohi STI | Kekemapa 17, 2019 |
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NCT04067011 | Emergent BioSolutions|Biomedical Advanced Research and Development Authority | Anthrax | ʻAukake 12, 2019 | Māhele 2 |
NCT02844634 | ʻO ka Hale Hōʻikeʻike o British Columbia no ka maʻi maʻi | HIV|Silipili | Mei 15, 2018 | Māhele 4 |
NCT00647959 | Mylan Pharmaceuticals | Ola ola | Malaki 2006 | Māhele 1 |
NCT00170222 | Hale Puka Lapaau Alkmaar | ʻO ka maʻi ʻāʻī ʻāʻī | Iulai 2002 | Māhele 4 |
NCT03075891 | Galderma | ʻO Rosacea | Iulai 5, 2017 | Māhele 4 |
NCT00031499 | National Institute of Allergy and Infectious Diseases (NIAID) | ʻO Syphilis | Iune 2000 | Māhele 3 |
NCT01205464 | Ke Kulanui ʻo Linkoeping | ʻO ka luhi|Ka ʻeha Radicular|Paresis|Paresis | Pepeluali 2005 | Pili ʻole |
NCT01301586 | ʻO Nexgen Dermatologic, Inc. | ANE VULGARIS | Nowemapa 2010 | Māhele 1|Mahele 2 |
NCT02305940 | Ke Kulanui Imperial Lākana | ʻO ka maʻi maʻi ʻāʻī ʻāʻī (COPD) | Iulai 2014 | Māhele 3 |
NCT00351182 | Dong-Min Kim|Chosun University Hospital | Holoi Typhus | Kepakemapa 2005 | Māhele 3 |
NCT03334682 | Halema'i Kula Nui o Nantes | ʻAneʻe vulgaris | Ianuali 31, 2018 | Māhele 3 |
NCT01788215 | Kulanui o Rochester | ʻO ka Polycystic Ovarian Syndrome (PCOS)|Kaʻi ʻana o ka manstrual Cycles|Ka nui o Androgen | Nowemapa 2010 | Māhele 3 |
NCT03076281 | ʻO Sidney Kimmel Cancer Center ma ke Kulanui ʻo Thomas Jefferson|Ke Kulanui ʻo Thomas Jefferson | Larynx|LEP|Waha waha|Pharynx | ʻApelila 3, 2017 | Māhele 2 |
NCT00439166 | Hamilton Health Sciences Corporation|The Physicians' Services Incorporated Foundation|Ke Kulanui o McMaster | ʻO ka maʻi o Alzheimer | Pepeluali 2007 | Māhele 3 |
NCT02463942 | Ke Kula Nui Lapaʻau Ljubljana|Ke Kula Lapaʻau o Ljubljana, Slovenia | ʻO Encephalitis maʻi maʻi | Kepakemapa 2014 | Pili ʻole |
NCT00803842 | Kulanui ʻĀkau komohana | ʻO ka maʻi maʻi maʻi ʻaʻole liʻiliʻi | ʻOkakopa 2008 | Pili ʻole |
NCT02086591 | Kulanui o Rochester | ʻO ka maʻi maʻi B-Cell Lymphoma Nui|Lymphoma Cell Mantle Recurrent|Lymphoma, Follicular|Marginal Zone B-Cell Lymphoma|Malignant Lymphoma - Lymphoplasmacytic|Waldenstrom Macroglobulinemia|Liʻiliʻi Lymphocytic Lymphoma|Chronic Lymphocytic Lymphoma-CLL) | | Malaki 2014 | Māhele 2 |
NCT03980223 | Ke Kulanui o Kaleponi, Kapalakiko|University of Washington|National Institute of Allergy and Infectious Diseases (NIAID)|Mayne Pharma International Pty Ltd|San Francisco Department of Public Health | Gonorrhea|Chlamydia|Syphilis | Nowemapa 26, 2019 | Māhele 4 |
NCT00355459 | Ke Kulanui o Texas Southwestern Medical Center | Ma'i Maka maloo | ʻAukake 2005 | Pili ʻole |
NCT01254799 | Omar Mamdouh Shaaban|Assiut University | ʻO ka ʻōpū o ka ʻōpū | Ianuali 2008 | Māhele 3 |
NCT01547325 | NanoSHIFT LLC|Keʻena Palekana o ʻAmelika Hui Pū ʻIa | Nā ʻEha Hoʻopaʻa ʻia | Mei 2012 | Pili ʻole |
NCT00653380 | Par Pharmaceutical, Inc.|Anapharm | No ka hoʻoholo ʻana i ka bioequivalence ma lalo o nā kūlana hoʻokē ʻai | Kepakemapa 1999 | Māhele 1 |
NCT00635609 | Warner Chilcott | ʻAneʻe vulgaris | Malaki 2008 | Māhele 4 |
NCT03765931 | Institut de Recherche pour le Development | ʻO ke kuni | Iulai 2016 | Māhele 4 |
NCT01160640 | Harold Wiesenfeld|Ke Kulanui o Pittsburgh | ʻO ka maʻi ʻaʻa ʻāʻī | Nowemapa 2010 | Māhele 2 |
NCT01756833 | Ke Kulanui o Maryland, Baltimore|National Institute on Aging (NIA) | Aneurysm | Mei 2013 | Māhele 2 |
NCT00688064 | Galderma | ʻO ka maʻi maʻi nui | ʻAukake 2008 | Māhele 3 |
NCT01320033 | Galderma | ʻAneʻe vulgaris | Malaki 29, 2011 | Māhele 2 |
NCT03397004 | St. Michael's Hospital, Toronto|Barrow Neurological Institute|Duke University|Feinstein Institute for Medical Research|University of Pittsburgh|Sunnybrook Health Sciences Center | Hoʻoilina Hemorrhagic Telangiectasia (HHT) | Kepakemapa 12, 2018 | Māhele 2 |
NCT01635530 | Halemai Kula Nui o Turku | ʻO Lyme Neuroborreliosis | ʻAukake 2012 | Māhele 4 |
NCT03727620 | Ke Kulanui ʻo Mohammed V Souissi | ʻO ka maʻi maʻi maʻi | Ianuali 6, 2014 | Māhele 1|Mahele 2 |
NCT02688738 | Rothman Institute Orthopedic | Propionibacterium | Malaki 2015 | Pili ʻole |
NCT00358462 | Ke Kulanui o Wakinekona|National Institute of Allergy and Infectious Diseases (NIAID) | Urethritis | Ianuali 2007 | Māhele 3 |
NCT02864550 | ʻO ka Hale Hōʻikeʻike o British Columbia no ka maʻi maʻi | Syphilis|Ma'i ma'i i lawe 'ia e ka wahine | ʻAukake 15, 2019 | Māhele 4 |
NCT01595594 | Ke Kulanui o Sao Paulo|Fundação de Amparo a Pesquisa do Estado de São Paulo | ʻO ka maʻi maʻi ʻokoʻa|Ka maʻi maʻi ʻano 2 | Malaki 2010 | Māhele 3 |
NCT00964834 | PharmAthene, Inc.|National Institute of Health (NIH)|Medarex|Quintiles, Inc.|Keʻena o ke Ola a me nā lawelawe kanaka | Anthrax | Iulai 2009 | Māhele 1 |
NCT01809444 | Ke Kulanui o Sun Yat-sen | Nā Ophthalmopathies pili i kouroid | Nowemapa 2012 | Māhele 2|Mahele 3 |
NCT01590082 | MD Anderson Cancer Center|National Institute of Health (NIH)|National Cancer Institute (NCI) | Melanoma | Nowemapa 2012 | Māhele 1|Mahele 2 |
NCT00207584 | Nā kikowaena no ka hoʻopaʻa ʻana a me ka pale ʻana i ka maʻi | Mycoplasma Pneumoniae | Ianuali 1994 | Pili ʻole |
NCT00775177 | ʻO Ranbaxy Laboratories Limited|Ranbaxy Inc. | Ola ola | Iune 2005 | Pili ʻole |
NCT03462329 | Ke Kulanui Lapaʻau Ljubljana | Erythema Migrans | Iune 1, 2018 | Pili ʻole |
NCT00000403 | Ke Kulanui o Indiana|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institute on Aging (NIA) | Osteoarthritis | Kepakemapa 1996 | Māhele 3 |
NCT03508232 | Ke Kulanui o Alberta|Ka Halemai Royal Alexandra | ST Segment Elevation Myocardial Infarction|Haʻule Puʻuwai | Ianuali 6, 2020 | Māhele 2 |
NCT02553473 | Halemai Sorlandet HF | ʻO Neuroborreliosis, Borrelia Burgdorferi | ʻOkakopa 2015 | Māhele 3 |
NCT02207556 | Ke Kulanui Lapaʻau o Wisconsin | ʻO ka Amyloidosis Systemic | ʻOkakopa 1, 2014 | Māhele 2 |
NCT01783106 | ʻO ka Halemai ʻo Royal Liverpool University|National Association for Colitis and Crohn's Disease|National Institute for Health Research, United Kingdom | ʻO ka maʻi o Crohn | Pepeluali 1, 2014 | Māhele 2 |
NCT00353743 | Halemai de Clinicas de Porto Alegre | Hoʻopaʻa keiki, Septic | Mei 2006 | Pili ʻole |
NCT01727973 | Ke Kulanui o Sun Yat-sen | Graves Ophthalmopathy|Ma'i Kupapau|Ma'i Maka|Ma'i Thyroid|Ma'i ma'i Endocrine System|Ma'i Maka, Ho'oilina|Hyperthyroidism|Ma'i Autoimmune|Ma'i Ka'i | ʻOkakopa 2012 | Māhele 1|Mahele 2 |
NCT00857038 | Lapaʻau Lapaʻau Alkmaar|Leiden University Medical Center|University of Amsterdam | ʻO ka maʻi maʻi ʻehaʻeha|Pulmonary Emphysema | ʻApelila 2009 | Māhele 4 |
NCT02774993 | Halemai Kula Nui o Lahui, Singapore|Hakapila o Tan Tock Seng|Ke Kula Nui, Singapore|A*Star | Ka maʻi maʻi maʻi | Kepakemapa 2015 | Māhele 2 |
NCT03474458 | IRCCS Policlinico S. Matteo | ʻO ka maʻi AL Amyloidosis | Pepeluali 11, 2019 | Māhele 2|Mahele 3 |
NCT02874430 | ʻO Sidney Kimmel Cancer Center ma ke Kulanui ʻo Thomas Jefferson|Ke Kulanui ʻo Thomas Jefferson | Ka ma'i ma'i o ka umauma|Adenocarcinoma ma'ema'e o ka ma'i endometrial | | Iune 8, 2016 | Māhele 2 |
NCT00016835 | Ke Kulanui o Michigan|National Institute of Dental and Craniofacial Research (NIDCR) | ʻO ka maʻi periodontal|Diabetes Mellitus, Type 2 | ʻOkakopa 17, 2001 | Māhele 2 |
NCT00064766 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Ke koko Endometrial|Ma'i Manawa | Pepeluali 2003 | Māhele 4 |
NCT00803452 | Kulanui o Louisville | Blepharitis | Iulai 2008 | Māhele 4 |
NCT01434173 | Bayer|RTI Health Solutions | ʻEha ʻĀpepa i hoʻohana ʻia i ka lāʻau | Iulai 2001 |
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NCT00126204 | Halema'i Barnes-Jewish | Aortic Aneurysm | Malaki 2004 | Pili ʻole |
NCT01917721 | Hawaii Pacific Health | ʻO ka maʻi ʻo Kawasaki|Coronary Aneurysm | ʻOkakopa 2013 | Māhele 2 |
NCT02775695 | Ke Kulanui Lapaʻau o Wisconsin | ʻO ka maʻi maʻi pancreatic hiki ke hoʻihoʻi ʻia | ʻApelila 3, 2017 | Māhele 2 |
NCT03824340 | Halemai Aljazeera | ʻAʻole hānau keiki | Ianuali 30, 2019 | Pili ʻole |
NCT01847976 | Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation | ʻeha | ʻAukake 2013 | Māhele 2 |
NCT02850913 | Ke Kulanui o Makerere|Ke Kulanui o Oxford | Hoʻopiʻi | Kepakemapa 5, 2016 | Māhele 2 |
NCT00764361 | NanoSHIFT LLC | Ka ma'i ma'i ma'i wāwae wāwae | Ianuali 2009 | Māhele 2 |
NCT02036528 | ʻO Royer Biomedical, Inc. | Ka ma'i ma'i ma'i wāwae wāwae | Ianuali 2014 | Māhele 1|Mahele 2 |
NCT01661985 | ʻAha Kūkākūkā Kalana ʻo Ostergotland, Suedena|Statens Serum Institut | Urethritis|Cervicitis|Ma'i Mycoplasma Genital|Chlamydia Trachomatis | Pepeluali 2010 | Māhele 4 |
NCT01380483 | Par Pharmaceutical, Inc.|Anapharm | No ka hoʻoholo ʻana i ka bioequivalence ma lalo o nā kūlana hoʻokē ʻai | Ianuali 2000 | Māhele 1 |
NCT00648180 | Mylan Pharmaceuticals | Ola ola | Iulai 2005 | Māhele 1 |
NCT01426269 | Galderma Laboratories, LP | ʻO Rosacea | Kepakemapa 2011 | Māhele 4 |
NCT02753426 | Ke Kulanui o Kaleponi, Kapalakiko | ʻO ka maʻi maʻi maʻi maʻi | | ʻApelila 2016 | Māhele 1 |
NCT02583282 | Postgraduate Institute of Medical Education and Research | ʻO ka hoʻoheheʻe ʻia ʻana o ka pleural malignant | ʻAukake 1, 2015 | Pili ʻole |
NCT02927496 | ʻO ka Task Force for Global Health|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Iune 19, 2018 | Māhele 3 |
NCT00652795 | Par Pharmaceutical, Inc.|Anapharm | No ka hoʻoholo ʻana i ka bioequivalence ma lalo o nā kūlana hoʻokē ʻai | Iulai 2004 | Māhele 1 |
NCT03956212 | Ke Kula Nui Lapaʻau Ljubljana|Ke Kula Lapaʻau o Ljubljana, Slovenia | Erythema Migrans | Iune 1, 2017 | Pili ʻole |
NCT00855595 | Bayer | Papulopustular Rosacea | Pepeluali 2009 | Māhele 4 |
NCT03457636 | Derm Research, PLLC | ʻAneʻe | Malaki 19, 2018 | Māhele 4 |
NCT02894268 | Sir Run Run Shaw Hospital | ʻO ka maʻi Helicobacter Pylori | Pepeluali 2016 | Māhele 4 |
NCT03465774 | MD Anderson Cancer Center|National Cancer Institute (NCI) | ʻO ka hoʻoheheʻe ʻia ʻana o ka pleural malignant | Malaki 8, 2018 | Māhele mua 1 |
ʻO ke kinona





Manaʻo18Nā papahana Loiloi Kūlike Kūlike i ʻae ʻia4, a6apono ʻia nā papahana.

Ua hoʻokumu ka ʻōnaehana hoʻokele maikaʻi honua kiʻekiʻe i ke kumu kūʻai.

Holo ka nānā ʻana i ka maikaʻi ma ke ola holoʻokoʻa o ka huahana e hōʻoia i ka maikaʻi a me ka hopena therapeutic.

Kākoʻo ka hui ʻoihana Regulatory Affairs i nā koi maikaʻi i ka wā o ke noi a me ke kākau inoa ʻana.


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