ʻO Chlorothiazide
Ka hope
ʻO Chlorothiazide kahi mea pale o carbonic anhydrase a ʻoi aku ka liʻiliʻi o ka ikaika ma mua o ka acetazolamide.Ua hōʻike ʻia kēia pūhui e pale i ka reabsorption o ka sodium a me ka chloride ion.
wehewehe
ʻO Chlorothiazide kahi diuretic a me ka antihypertensive.(IC50=3.8 mM) Manaʻo: ʻO nā mea ʻē aʻe ʻo Chlorothiazide sodium (Diuril) he diuretic i hoʻohana ʻia i loko o ke kahua o ka haukapila a i ʻole no ka hoʻohana pilikino no ka mālama ʻana i ka wai nui e pili ana me ka puʻuwai congestive.Hoʻohana ʻia ia ma ke ʻano he antihypertensive.Lawe pinepine ʻia ma ke ʻano pila, lawe ʻia ma ka waha hoʻokahi a ʻelua paha i ka lā.I ka hoʻonohonoho ICU, hāʻawi ʻia ka chlorothiazide e diurese i ka mea maʻi me ka furosemide (Lasix).Ke hana nei ma kahi ʻano hana ʻokoʻa ma mua o ka furosemide, a komo i loko o ka enterically e like me ka hoʻokuʻu hou ʻana i lawelawe ʻia ma o ka nasogastric tube (NG tube), ʻelua mau lāʻau lapaʻau e potentiate kekahi i kekahi.
ʻO ka hoʻokolohua lapaʻau
Helu NCT | Kākoʻo | Kūlana | Lā Hoʻomaka | Māhele |
NCT03574857 | Kulanui o Virginia | Puuwai Puuwai|Puuwai Puuwai Me ka Hoemi Ejection Fraction|Puuwai Puuwai Acute|Ma'i Pu'uwai | Iune 2018 | Māhele 4 |
NCT02546583 | Ke Kula Nui ʻo Yale|National Heart, Lung, and Blood Institute (NHLBI) | Puuwai Puuwai | ʻAukake 2015 | Pili 'ole |
NCT02606253 | Ke Kulanui ʻo Vanderbilt|Ke Kula Nui ʻo Vanderbilt | Puuwai Puuwai | Pepeluali 2016 | Māhele 4 |
NCT00004360 | Ke Kikowaena Lahui no na Punawai Noi (NCRR)|Ke Kulanui o Northwestern|Ke Keʻena o nā maʻi Lakaʻikaʻi (ORD) | Diabetes Insipidus, Nephrogenic | Kepakemapa 1995 |
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NCT00000484 | National Heart, Lung, and Blood Institute (NHLBI) | Na Ma'i Pu'uwai|Ma'i Pu'uwai|Ma'i Pu'uwai|Ma'i Pu'uwai | ʻApelila 1966 | Māhele 3 |
ʻO ke kinona
Manaʻo18Nā papahana Loiloi Kūlike Kūlike i ʻae ʻia4, a6nā papahana ma lalo o ka ʻae ʻia.
Ua hoʻokumu ka ʻōnaehana hoʻokele maikaʻi honua kiʻekiʻe i ke kumu kūʻai.
Holo ka nānā ʻana i ka maikaʻi ma ke ola holoʻokoʻa o ka huahana e hōʻoia i ka maikaʻi a me ka hopena therapeutic.
Kākoʻo ka hui ʻoihana Regulatory Affairs i nā koi maikaʻi i ka wā o ke noi a me ke kau inoa ʻana.