ʻO Rosuvastatin (inoa inoa ʻo Crestor, kūʻai ʻia e AstraZeneca) kekahi o nā lāʻau statin i hoʻohana pinepine ʻia. E like me nā statins ʻē aʻe, kuhikuhi ʻia ʻo rosuvastatin e hoʻomaikaʻi i ka pae lipid koko o ke kanaka a e hōʻemi i ka pilikia cardiovascular.

I loko o nā makahiki he ʻumi mua a i ʻole ka rosuvastatin ma ka mākeke, ua hoʻolaha nui ʻia ʻo ia ma ke ʻano he "statin o nā hanauna ʻekolu," a no laila ʻoi aku ka maikaʻi a hiki i ka liʻiliʻi o nā hopena ʻino ma mua o ka hapa nui o nā lāʻau statin. I ka hala ʻana o nā makahiki a ʻoiai ua hōʻuluʻulu ʻia nā hōʻike mai nā hoʻokolohua lapaʻau, ʻoi aku ka nui o ka hoihoi mua no kēia statin kūikawā.

Ke noʻonoʻo nei ka hapa nui o nā loea i nā pilikia pili a me nā pono o ka rosuvastatin e like me nā statins ʻē aʻe. Eia nō naʻe, aia kekahi mau kūlana lapaʻau i makemake ʻia ai ka rosuvastatin.

ʻO ka hoʻohana ʻana o Rosuvastatin

Hoʻokumu ʻia nā lāʻau statin e hōʻemi i ka cholesterol koko. Hoʻopili kēia mau lāʻau lapaʻau i ka enzyme ate i kapa ʻia ʻo hydroxymethylglutaryl (HMG) CoA reductase. Hoʻokani ʻo HMG CoA reductase i ka hana hoʻokaʻawale i ka synthesis o ka cholesterol e ke ake.

Ma ka pale ʻana i ka HMG CoA reductase, hiki i nā statins ke hoʻemi nui i ka hana ʻana o ka cholesterol LDL ("ʻino") i loko o ke ake, a no laila hiki ke hoʻemi i ka pae koko LDL cholesterol ma kahi o 60%. Eia kekahi, hoʻohaʻahaʻa haʻahaʻa nā statins i ke kiʻekiʻe o ke koko triglyceride (ma kahi o 20-40%), a hoʻonui liʻiliʻi (ma kahi o 5%) i ke kiʻekiʻe o ke koko o HDL cholesterol ("kolesterol maikaʻi").

Me ka ʻokoʻa o nā mea hoʻopaneʻe PCSK9 i hoʻomohala hou ʻia, ʻo nā statins nā lāʻau hōʻemi cholesterol ikaika loa i loaʻa. Eia kekahi, ʻokoʻa i nā papa ʻē aʻe o nā lāʻau hoʻohaʻahaʻa i ka cholesterol, ua hōʻike nā hoʻokolohua lapaʻau e hiki i nā lāʻau statin ke hoʻomaikaʻi nui i nā hopena lōʻihi o nā poʻe me ka maʻi coronary artery (CAD), a me nā poʻe i ke kūlana haʻahaʻa a kiʻekiʻe paha o ka hoʻomohala ʻana i ka CAD. .

Hoʻemi nui nā statins i ka hopena o nā hōʻeha puʻuwai ma hope, a hoʻohaʻahaʻa i ka hopena o ka make mai CAD. (Ua hōʻike ʻia nā mea hoʻopaneʻe PCSK9 hou i nā RCT nui e hoʻomaikaʻi i nā hopena lapaʻau.)

ʻO kēia hiki o nā statins e hoʻomaikaʻi nui i nā hopena lapaʻau i manaʻo ʻia e hopena, ma ka liʻiliʻi loa, mai kekahi a i ʻole nā ​​​​mea āpau o kā lākou mau pono hoʻohaʻahaʻa ʻole i ka cholesterol. Ma waho aʻe o ka hoʻohaʻahaʻa ʻana i ka kolamu LDL, loaʻa i nā statins nā waiwai anti-inflammatory, nā hopena anti-blood clotting, a me nā waiwai hoʻopaʻa i ka plaque. Eia kekahi, hoʻemi kēia mau lāʻau lapaʻau i nā pae protein C-reactive, hoʻomaikaʻi i ka hana vascular holoʻokoʻa, a hoʻemi i ka hopena o nā arrhythmias cardiac hoʻoweliweli.

Loaʻa paha nā pono lapaʻau i hōʻike ʻia e nā lāʻau statin ma muli o ka hui pū ʻana o kā lākou mau hopena hoʻohaʻahaʻa cholesterol a me kā lākou ʻano like ʻole o nā hopena non-cholesterol.

Pehea ka ʻokoʻa o Rosuvastatin?

ʻO Rosuvastatin kahi lāʻau statin hou, i kapa ʻia ʻo "ʻekolu-hanauna". ʻO ka mea nui, ʻo ia ka lāʻau statin ikaika loa ma ka mākeke.

Loaʻa kona ikaika pili mai kona mau hiʻohiʻona kemika, kahi e hiki ai iā ia ke hoʻopaʻa paʻa i ka HMG CoA reductase, no laila e hoʻokō ai i kahi kaohi piha ʻana o kēia enzyme. ʻO ka molekula no ka mole, ʻo ka rosuvastatin ka mea e hoʻonui ai i ka LDL-cholesterol-hoʻohaʻahaʻa ma mua o nā lāʻau statin ʻē aʻe. Eia nō naʻe, hiki ke hoʻokō ʻia ka nui like o ka hoʻohaʻahaʻa ʻana i ka cholesterol ma ka hoʻohana ʻana i nā kiʻekiʻe kiʻekiʻe o ka hapa nui o nā statins.

Ke koi ʻia ka lāʻau statin "koʻikoʻi" e hoʻokuʻu i nā pae cholesterol i haʻahaʻa loa, ʻo ka rosuvastatin ka lāʻau hele no nā kauka he nui.

ʻO ka hopena o Rosuvastatin

Ua loaʻa ʻo Rosuvastatin i kahi kūlana maikaʻi loa i waena o nā lāʻau statin, ʻo ka mea nui ma muli o nā hopena o nā hoʻokolohua lapaʻau ʻelua.

I ka makahiki 2008, ua hoʻopuka ʻia ka noiʻi ʻo JUPITER i ka manaʻo o nā cardiologists ma nā wahi āpau. Ma kēia noiʻi ʻana, ʻoi aku ma mua o 17,000 mau kānaka olakino i loaʻa nā pae koko LDL cholesterol maʻamau akā ua hoʻokiʻekiʻe ʻia nā pae CRP e loaʻa i ka 20 mg i kēlā me kēia lā o ka rosuvastatin a i kahi placebo.

I ka wā o ka hahai ʻana, ʻaʻole i hoʻohaʻahaʻa nui ka poʻe i ka rosuvastatin i nā pae LDL cholesterol a me nā pae CRP, akā ua liʻiliʻi loa lākou i nā hanana cardiovascular (me ka puʻuwai puʻuwai, ka hahau ʻana, ka pono no kahi kaʻina hana revascularization e like me ka stent a i ʻole ka bypass surgery. a me ka hui pū ʻana o ka maʻi ʻeha puʻuwai, a i ʻole ka make ʻana o ka maʻi cardiovascular), a me ka hōʻemi ʻana i nā kumu make āpau.

He mea kupaianaha kēia haʻawina ʻaʻole wale no ka hoʻomaikaʻi nui ʻana o ka rosuvastatin i nā hopena lapaʻau i nā poʻe olakino olakino, akā no ka mea ʻaʻole i hoʻokiʻekiʻe kēia poʻe i nā pae cholesterol i ka manawa o ke kau inoa ʻana.

Ma 2016, ua paʻi ʻia ka hoʻokolokolo HOPE-3. Ua hoʻopaʻa inoa kēia haʻawina ma luna o 12,000 poʻe me ka liʻiliʻi hoʻokahi kumu pilikia no ka maʻi atherosclerotic vascular, akā ʻaʻohe CAD. Ua hoʻokaʻawale ʻia nā mea komo i ka rosuvastatin a i ʻole placebo. I ka pau ʻana o ka makahiki, ua emi nui ka poʻe e lawe ana i ka rosuvastatin i kahi hopena hopena composite (me ka puʻuwai make ʻole a i ʻole ka hahau ʻana, a i ʻole ka make mai ka maʻi cardiovascular).

I loko o kēia mau ho'āʻo ʻelua, ua hoʻomaikaʻi nui ka randomization i ka rosuvastatin i nā hopena lapaʻau o ka poʻe i loaʻa hoʻokahi a ʻoi aku paha nā mea pilikia, akā ʻaʻohe hōʻailona o ka maʻi cardiovascular ikaika.

Pono e hoʻomaopopo ʻia ua koho ʻia ka rosuvastatin no kēia mau hoʻāʻo ʻaʻole no ka mea ʻoi aku ka ikaika o nā lāʻau statin, akā (ma ka liʻiliʻi loa ma ka hapa nui) no ka mea ua kākoʻo ʻia nā hoʻokolohua e AstraZeneca, ka mea hana rosuvastatin.

Manaʻo ka hapa nui o ka poʻe loea lipid e like nā hopena o kēia mau ho'āʻo inā hoʻohana ʻia kekahi statin i ka nui o ka nui, a ʻo ka ʻoiaʻiʻo, ʻo nā ʻōlelo aʻoaʻo o kēia manawa e pili ana i ka lāʻau me nā lāʻau statin e ʻae i ka hoʻohana ʻana i kekahi o nā lāʻau statin e like me ka lōʻihi. He kiʻekiʻe ke kiʻekiʻe e hiki ai ke loaʻa i ka pae like o ka hoʻohaʻahaʻa cholesterol e like me ka mea e loaʻa ai me ka haʻahaʻa haʻahaʻa o rosuvastatin. (Hoʻokoe ʻia kēia lula maʻamau i ka wā e kāhea ʻia ai ka "intensive statin therapy".

Akā no ka mea ʻo rosuvastatin ka statin i hoʻohana ʻia i kēia mau hoʻokolohua lapaʻau koʻikoʻi ʻelua, nui nā kauka i hōʻole i ka hoʻohana ʻana i ka rosuvastatin ma ke ʻano he statin koho.

Nā hōʻailona o kēia manawa

Hōʻike ʻia ka lāʻau statin no ka hoʻomaikaʻi ʻana i ke kiʻekiʻe o ka lipid koko (ʻoi aku, e hōʻemi i ka LDL cholesterol a/a i nā pae triglyceride), a no ka pale ʻana i ka maʻi cardiovascular. Manaʻo ʻia nā statins no ka poʻe i loaʻa i ka maʻi cardiovascular atherosclerotic, ka poʻe me ka maʻi diabetes, a me ka poʻe i manaʻo ʻia he 10 mau makahiki ka hopena o ka hoʻomohala ʻana i ka maʻi cardiovascular ma luna o 7.5% a 10%.

ʻOiai, ma ka laulā, ua manaʻo ʻia nā lāʻau statin e hoʻololi ʻia e pili ana i ko lākou hopena a me ko lākou pilikia e hoʻokau i nā hanana pōʻino, aia kekahi mau manawa e makemake ʻia ai ka rosuvastatin. ʻO ka mea kikoʻī, ke kuhikuhi ʻia ka lāʻau statin "high-intensity" i ka hōʻemi ʻana i ka LDL cholesterol i nā pae haʻahaʻa haʻahaʻa loa, ʻo ka rosuvastatin a i ʻole ka atorvastatin ma kā lākou mau pae kiʻekiʻe kiʻekiʻe.

Ma mua o ka lawe ʻana

Ma mua o kou kuhikuhi ʻana i kekahi lāʻau statin, e hana kāu kauka i kahi loiloi koʻikoʻi maʻamau e hoʻohālikelike i kou pilikia o ka hoʻomohala ʻana i ka maʻi cardiovascular a e ana i kou pae lipid koko. Inā loaʻa iā ʻoe ka maʻi maʻi maʻi cardiovascular a i ʻole ke piʻi nui ʻana o ka hoʻomohala ʻana, e ʻōlelo paha kāu kauka i kahi lāʻau statin.

ʻO nā lāʻau statin ʻē aʻe i kuhikuhi pinepine ʻia ʻo atorvastatin, simvastatin, fluvastatin, lovastatin, pitavastatin, a me pravastatin.

ʻO Crestor, ka inoa inoa inoa o rosuvastatin ma US, he kumukūʻai nui, akā aia nā ʻano generic o rosuvastatin i kēia manawa. Inā makemake kāu kauka e lawe i ka rosuvastatin, e nīnau inā hiki iā ʻoe ke hoʻohana i ka generic.

ʻAʻole pono e hoʻohana ʻia nā statins i ka poʻe maʻi i nā statins a i ʻole kekahi o kā lākou meaʻai, ka poʻe hāpai a hānai ʻana paha, ka poʻe i loaʻa i ka maʻi ate a i ʻole ka hōʻole ʻole o ka renal, a i ʻole ka mea inu nui i ka waiʻona. Hōʻike nā haʻawina e hiki ke hoʻohana palekana i ka rosuvastatin i nā keiki ma mua o 10 mau makahiki.

Ka hoʻohana ʻana o Rosuvastatin

Ke hoʻohana ʻia nei ka rosuvastatin e hōʻemi i ke kiʻekiʻe o ka LDL cholesterol kiʻekiʻe, ʻo ka maʻamau e hoʻomaka ʻia nā haʻahaʻa haʻahaʻa (5 a 10 mg i kēlā me kēia lā) a hoʻoponopono ʻia i luna i kēlā me kēia mahina a ʻelua paha e like me ka mea e pono ai. I ka poʻe me ka hypercholesterolemia ʻohana, hoʻomaka nā kauka me nā ʻano kiʻekiʻe aʻe (10 a 20 mg i kēlā me kēia lā).

Ke hoʻohana ʻia nei ka rosuvastatin e hōʻemi i ka hopena o ka maʻi cardiovascular i ka poʻe me ka haʻahaʻa kiʻekiʻe o ka pilikia, ʻo ka nui o ka hoʻomaka ʻana he 5 a 10 mg i kēlā me kēia lā. I ka poʻe i manaʻo ʻia he kiʻekiʻe ka pilikia (ʻo ia hoʻi, ʻoi aku ka nui o ko lākou 10 mau makahiki ma luna o 7.5%), hoʻomaka pinepine ka lāʻau lapaʻau kiʻekiʻe, me 20 a 40 mg i kēlā me kēia lā.

Inā hoʻohana ʻia ka rosuvastatin e hōʻemi i ka hopena o nā hanana cardiovascular hou i kahi kanaka me ka maʻi cardiovascular i hoʻokumu ʻia, hoʻohana pinepine ʻia ka mālama koʻikoʻi me ka nui o 20 a 40 mg i kēlā me kēia lā.

I ka poʻe e lawe ana i ka cyclosporine a i ʻole nā ​​lāʻau lapaʻau no ka maʻi HIV/AIDS, a i ʻole i ka poʻe me ka hana hōʻemi o ka hana ʻana, pono e hoʻoponopono ʻia ka nui o ka rosuvastatin i lalo, a ʻaʻole pono ma mua o 10 mg i kēlā me kēia lā.

ʻOi aku ka maʻalahi o ka poʻe o ka lāhui ʻAsia i nā lāʻau statin a ʻoi aku ka maʻalahi i nā hopena ʻaoʻao. Manaʻo pinepine ʻia e hoʻomaka ka rosuvastatin ma ka 5 mg i kēlā me kēia lā a hoʻonui lohi i nā mea maʻi ma Asia.

Lawe ʻia ʻo Rosuvastatin i hoʻokahi manawa i ka lā, a hiki ke lawe ʻia i ke kakahiaka a i ke ahiahi paha. ʻAʻole like me kekahi o nā lāʻau statin ʻē aʻe, ʻo ka inu ʻana i ka wai liʻiliʻi liʻiliʻi ka hopena o ka rosuvastatin.

Nā hopena ʻaoʻao o Rosuvastatin

I nā makahiki ma hope koke iho o ka hoʻomohala ʻana o ka rosuvastatin, nui ka poʻe loea i hōʻike i ka liʻiliʻi o nā hopena ʻaoʻao statin me ka rosuvastatin, no ka mea hiki ke hoʻohana ʻia nā haʻahaʻa haʻahaʻa e hoʻokō i ka hōʻemi ʻana o ka cholesterol. I ka manawa like, ua ʻōlelo ka poʻe loea ʻē aʻe e hoʻonui ʻia nā hopena ʻaoʻao statin me kēia lāʻau lapaʻau, ʻoiai ʻoi aku ka ikaika ma mua o nā statins ʻē aʻe.

I nā makahiki i hala iho nei, ua ʻike ʻia ʻaʻole pololei ka ʻōlelo. Me he mea lā ua like ke ʻano a me ka nui o nā hopena ʻino me ka rosuvastatin e like me nā lāʻau statin ʻē aʻe.

ʻOi aku ka maikaʻi o nā statins, ma ke ʻano he hui, ma mua o nā lāʻau hōʻemi cholesterol. I loko o kahi meta-analysis i paʻi ʻia ma 2017 i nānā i 22 randomized clinical trials, ʻo 13.3% wale nō o ka poʻe randomized i kahi lāʻau statin i hoʻopau i ka lāʻau ma muli o nā hopena ʻaoʻao i loko o 4 mau makahiki, ke hoʻohālikelike ʻia me 13.9% o ka poʻe randomized i placebo.

Eia nō naʻe, aia nā hopena ʻaoʻao i ʻike ʻia e nā lāʻau statin, a pili kēia mau hopena ʻaoʻao i ka rosuvastatin a me nā statin ʻē aʻe. ʻO ka mea kaulana loa o kēia mau hopena ʻaoʻao:

• Nā hanana ʻino pili i ka ʻiʻo. Hiki ke kumu o ka ʻona o ka ʻiʻo e nā statins. Hiki i nā hōʻailona ke komo i ka myalgia (ʻeha o ka ʻiʻo), nāwaliwali o ka ʻiʻo, ka ʻāʻī o ka ʻiʻo, a i ʻole (ma nā hihia koʻikoʻi) rhabdomyolysls. ʻO ka Rhabdomyolysis ka hōʻino ʻole o ka renal ma muli o ka haki ʻana o ka ʻiʻo. I ka nui o na hihia. Hiki ke hoʻomalu ʻia nā hopena ʻaoʻao pili i ka ʻiʻo ma ka hoʻololi ʻana i kekahi statin. ʻO Rosuvastatin kekahi o nā lāʻau statin i ʻike ʻia he mea liʻiliʻi ka ʻona o ka ʻiʻo. ʻO ka ʻokoʻa, ʻoi aku ka maʻalahi o ka lovastatin, simvastatin, a me atorvastatin i mea e hoʻopilikia ai i ka ʻiʻo.
• Nā pilikia o ke ake. Ma kahi o 3% o ka poʻe e lawe ana i nā statins e hoʻonui i nā enzyme ate i ko lākou koko. I ka hapa nui o kēia poʻe, ʻaʻole ʻike ʻia kahi hōʻike o ka pōʻino o ke ake maoli, a ʻaʻole maopopo ke koʻikoʻi o kēia kiʻekiʻe liʻiliʻi i nā enzymes. I loko o kahi poʻe liʻiliʻi loa, ua hōʻike ʻia ka ʻeha nui o ke ake; ʻAʻole maopopo, akā, ʻoi aku ka nui o ka hōʻeha o ke akepaʻa i nā poʻe e lawe ana i nā statins ma mua o ka lehulehu. ʻAʻohe mea hōʻike e hoʻohua ai ka rosuvastatin i nā pilikia o ka ate ma mua o nā statins ʻē aʻe.
• Hoʻopilikia i ka naʻau. Ua hāpai ʻia ka manaʻo e hiki i nā statins ke hōʻeha i ka naʻau, ka nalowale hoʻomanaʻo, ke kaumaha, ka huhū, ka huhū, a i ʻole nā ​​​​hopena ʻōnaehana ʻē aʻe o ke kikowaena, akā ʻaʻole i hōʻike maopopo ʻia. I ka nānā ʻana i nā hōʻike hihia i hoʻouna ʻia i ka FDA, ʻike ʻia nā pilikia cognitive e pili ana me nā statins me nā lāʻau lipophilic statin, me atorvastatin, fluvastatin, lovastatin, a me simvastatin. ʻO nā lāʻau hydrophilic statin, me ka rosuvastatin, ua hoʻopili pinepine ʻia me kēia hanana ʻino.
• Diabetes. I nā makahiki i hala iho nei, ua pili ka piʻi liʻiliʻi o ka hoʻomohala ʻana o ka maʻi diabetes me ka statin therapy. Ma ka 2011 meta-analysis o ʻelima mau hoʻokolohua lapaʻau e hōʻike ana e loaʻa kahi maʻi maʻi diabetes i kēlā me kēia 500 poʻe i mālama ʻia me nā statins kiʻekiʻe. Ma keʻano laulā, manaʻo ʻia kēia pae o ka pilikia inā lōʻihi ka manaʻo o ka statin e hōʻemi nui i ka pilikia cardiovascular holoʻokoʻa.

ʻO nā hopena ʻaoʻao ʻē aʻe i hōʻike pinepine ʻia me nā lāʻau statin e pili ana i ka nausea, ka maʻi ʻeha, a me ka ʻeha hui.

Nā pilina

Hiki i ka lawe ʻana i kekahi mau lāʻau lapaʻau ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i nā hopena ʻaoʻao me rosuvastatin (a i ʻole kekahi statin). He lōʻihi kēia papa inoa, akā ʻo nā lāʻau lapaʻau kaulana loa e launa pū me ka rosuvastatin:

• ʻO Gemfibrozil, kahi mea hoʻohaʻahaʻa cholesterol non-statin
• ʻO Amiodarone, kahi lāʻau anti-arrhythmic
• ʻO kekahi o nā lāʻau HIV
• ʻO kekahi mau lāʻau lapaʻau, ʻoi aku ka clarithromycin a me ka itraconazone
• ʻO Cyclosporine, kahi lāʻau immunosuppressant

He huaolelo mai Verywell

ʻOiai ʻo rosuvastatin ka statin ikaika loa i loaʻa, ma ka laulā, ua like loa kona hopena a me kona ʻano ʻawaʻawa me nā statins ʻē aʻe. Eia nō naʻe, aia kekahi mau kūlana lapaʻau i ʻoi aku ka maikaʻi o ka rosuvastatin ma mua o nā lāʻau statin ʻē aʻe.