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ʻO ka Hydrochlorothiazide (HCTZ), kahi lāʻau diuretic waha o ka papa thiazide, ke kāohi nei i ka hoʻololi ʻana o TGF-β/ Alanui hōʻailona Smad. Loaʻa ka Hydrochlorothiazide i nā hopena hoʻomaha vascular ma o ka wehe ʻana i ke kahawai calcium-activated potassium (KCA). Hoʻomaikaʻi ʻo Hydrochlorothiazide i ka hana cardiac, hōʻemi i ka fibrosis a he hopena antihypertensive.

Kāpae

ʻO ka Hydrochlorothiazide kahi lāʻau diuretic o ka papa thiazide.

In Vitro

Aia ka Hydrochlorothiazide i ka papa thiazide o diuretics. Hoʻemi ia i ka nui o ke koko ma ka hana ʻana i nā puʻupaʻa e hōʻemi i ka hoʻihoʻi hou ʻana o ka sodium (Na) i loko o ka tubule convoluted distal. ʻIke ʻia ka pae nui o ka hana i loko o ka nephron ma kahi electroneutral Na+-Cl co-transporter ma o ka hoʻokūkū ʻana no ke kahua chloride ma ka mea lawe. Ma ka hoʻopilikia ʻana i ka lawe ʻana o Na i loko o ka tubule convoluted distal, hydrochlorothiazide e hoʻoulu i ka natriuresis a me ka nalowale o ka wai. Hoʻonui ka Thiazides i ka reabsorption o ka calcium i kēia ʻāpana ma kahi ʻano pili ʻole i ka lawe ʻana i ka sodium. Hoʻohui ʻia, ma o nā ʻano hana ʻē aʻe, ua manaʻo ʻia ʻo Hydrochlorothiazide e hoʻohaʻahaʻa i ka pale ʻana o nā vascular peripheral.

Ua hoʻomaikaʻi ʻo Hydrochlorothiazide (HCTZ; 12.5 mg/kg/d; 8 mau pule) i ka hana naʻau, hoʻemi i ka fibrosis interstitial cardiac a me ka hapa nui o ka collagen, hōʻemi i ka hōʻike o AT1, TGF-β a me Smad2 i loko o nā ʻiʻo puʻuwai i nā ʻiole kāne makua Sprague Dawley. Eia kekahi, hoʻemi ka hydrochlorothiazide i ka plasma angiotensin II a me ka pae aldosterone. Eia kekahi, ke kāohi nei ka hydrochlorothiazide i ka angiotensin II-induced TGF-β1 a me Smad2 hōʻike protein i ka neonatal rat ventricular fibroblasts.

ʻO ke kinona